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Expression of fibroblast growth factor receptor 4 and clinical response to lenvatinib in patients with anaplastic thyroid carcinoma: a pilot study

Abstract

Purpose

Fibroblast growth factor receptor 4 (FGFR4) expression has association with tumor malignancy. In thyroid cancers, FGFR4 has been reported to be characteristically expressed in aggressive thyroid tumors, such as anaplastic thyroid carcinoma (ATC).

Methods

We investigated FGFR4 expression in patients with ATC and analyzed their clinical responses to lenvatinib. Primary tumor samples were obtained from 12 patients with ATC who underwent surgery or core needle biopsy. FGFR4 protein expression in all ATC samples was analyzed via immunohistochemistry, and the treatment efficacy of lenvatinib was evaluated.

Results

The proportion of FGFR4-positive cells in the samples ranged from 0 to 50%. Four patients had partial responses, and three patients had stable diseases as a best clinical response to lenvatinib. The median PFS durations of patients with none, weak, and moderate intensity were 0.5, 3.2 (95% CI 1.1–not estimable [NE]), and 4.6 (95% CI 1.1–NE) months, respectively (p = 0.003).

Conclusions

Because FGFR4 was expressed in ATC tissues, the FGFR4 expression might be associated with the treatment efficacy of lenvatinib in a part of ATC patients. To clarify whether FGFR4 can serve as a prognostic or predictive factor for lenvatinib therapy, more cases must be accumulated.

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Acknowledgments

We thank Enago (https://www.enago.jp/) for editing a draft of this manuscript.

Author information

HY prepared the manuscript. TY, HH, and SO performed pathological and immunohistochemical examinations. HI, NS, HN, and KM cared for the patient. YR and MM comprehensively supervised this case report. All authors read and approved the final manuscript.

Correspondence to Haruhiko Yamazaki.

Ethics declarations

Written informed consent was obtained from all patients before inclusion in the study. The study protocol was approved by the institutional review board of Kanagawa Cancer Center.

Conflict of interest

The authors declare that they have no competing interests.

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Yamazaki, H., Yokose, T., Hayashi, H. et al. Expression of fibroblast growth factor receptor 4 and clinical response to lenvatinib in patients with anaplastic thyroid carcinoma: a pilot study. Eur J Clin Pharmacol (2020). https://doi.org/10.1007/s00228-020-02842-y

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Keywords

  • Thyroid cancer
  • Molecular biology
  • Clinical research
  • Lenvatinib
  • Fibroblast growth factor receptor