Comment on “Is cinnarizine/betahistine combination superior to respective monotherapies in treatment of vertigo? A randomized triple-blind placebo-controlled trial”

  • Alireza Majdi
  • Seyed Ahmad Naseri AlaviEmail author
Letter to the Editor

The paper published recently by Asadi et al. [1] was set to investigate the superiority of cinnarizine/betahistine combination compared with the respected monotherapies in patients with acute peripheral vertigo (APV).

In the respected letter to the editor by Amini and Taghizadeh-Ghehi, the quality of our recently published article has been questioned based on two papers. As opposed to our study, the study by Murdin et al. [2] demonstrated a well-tolerated use of betahistine in patients with any type of vertigo. The other study by Vanderkam et al. [3] was a review study which investigated the efficacy of acetyl leucine in patients with vertigo and dizziness. The authors found no evidence related to the efficacy of acetyl leucine in patients with vertigo or dizziness. The paper by Asadi et al. [1] was not, however, about acetyl leucine and its efficacy in vertigo. So the relationship between these papers with our study is not apparent.

Further, the authors have questioned the usage of...



  1. 1.
    Asadi P, Zia Ziabari SM, Majdi A, Vatanparast K, Naseri Alavi SA (2019) Cinnarizine/betahistine combination vs. the respective monotherapies in acute peripheral vertigo: a randomized triple-blind placebo-controlled trial. Eur J Clin Pharmacol 75(11):1513–1519. CrossRefPubMedGoogle Scholar
  2. 2.
    Murdin L, Hussain K, Schilder AGM (2016) Betahistine for symptoms of vertigo. Cochrane Database Syst Rev 6.
  3. 3.
    Vanderkam P, Blanchard C, Naudet F, Pouchain D, Vaillant Roussel H, Perault-Pochat MC, Jaafari N, Boussageon R (2019) Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials. Eur J Clin Pharmacol 75(5):603–607. CrossRefPubMedGoogle Scholar
  4. 4.
    Değerli V et al (2007) Comparison of intraveneous diazepam, dimenhydrinate and diphenhydramine on patients with acute peripheral vertigo in the emergency department: a randomized, double blind, clinical trial. Turk J Emerg Med 7(1):010–017Google Scholar
  5. 5.
    Irving C et al (2002) Intramuscular droperidol versus intramuscular dimenhydrinate for the treatment of acute peripheral vertigo in the emergency department: a randomized clinical trial. Acad Emerg Med 9(6):650–653CrossRefGoogle Scholar
  6. 6.
    Casani AP, Dallan I, Cerchiai N, Lenzi R, Cosottini M, Sellari-Franceschini S (2013) Cerebellar infarctions mimicking acute peripheral vertigo: how to avoid misdiagnosis? Otolaryngol Head Neck Surg 148(3):475–481. CrossRefPubMedGoogle Scholar
  7. 7.
    Fattori B, Nacci A, Ghilardi PL, Bruschini L, Matteucci F, Ursino F (2003) Acute peripheral vertigo: involvement of the hemostatic system. Int Tinnitus J 9(2):124–129PubMedGoogle Scholar
  8. 8.
    Motamed H, Moezzi M, Rooyfard AD, Angali KA, Izadi Z (2017) A comparison of the effects and side effects of oral betahistine with injectable promethazine in the treatment of acute peripheral vertigo in emergency. J Clin Med Res 9(12):994–997. CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Neuroscience Research CenterTabriz University of Medical SciencesTabrizIran
  2. 2.Department of NeurosurgeryTabriz University of Medical SciencesTabrizIran

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