Comment on “Is cinnarizine/betahistine combination superior to respective monotherapies in treatment of vertigo? A randomized triple-blind placebo-controlled trial”
- 3 Downloads
The paper published recently by Asadi et al.  was set to investigate the superiority of cinnarizine/betahistine combination compared with the respected monotherapies in patients with acute peripheral vertigo (APV).
In the respected letter to the editor by Amini and Taghizadeh-Ghehi, the quality of our recently published article has been questioned based on two papers. As opposed to our study, the study by Murdin et al.  demonstrated a well-tolerated use of betahistine in patients with any type of vertigo. The other study by Vanderkam et al.  was a review study which investigated the efficacy of acetyl leucine in patients with vertigo and dizziness. The authors found no evidence related to the efficacy of acetyl leucine in patients with vertigo or dizziness. The paper by Asadi et al.  was not, however, about acetyl leucine and its efficacy in vertigo. So the relationship between these papers with our study is not apparent.
Further, the authors have questioned the usage of...
- 1.Asadi P, Zia Ziabari SM, Majdi A, Vatanparast K, Naseri Alavi SA (2019) Cinnarizine/betahistine combination vs. the respective monotherapies in acute peripheral vertigo: a randomized triple-blind placebo-controlled trial. Eur J Clin Pharmacol 75(11):1513–1519. https://doi.org/10.1007/s00228-019-02741-x CrossRefPubMedGoogle Scholar
- 2.Murdin L, Hussain K, Schilder AGM (2016) Betahistine for symptoms of vertigo. Cochrane Database Syst Rev 6. https://doi.org/10.1002/14651858.CD010696.pub2
- 3.Vanderkam P, Blanchard C, Naudet F, Pouchain D, Vaillant Roussel H, Perault-Pochat MC, Jaafari N, Boussageon R (2019) Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials. Eur J Clin Pharmacol 75(5):603–607. https://doi.org/10.1007/s00228-018-02617-6 CrossRefPubMedGoogle Scholar
- 4.Değerli V et al (2007) Comparison of intraveneous diazepam, dimenhydrinate and diphenhydramine on patients with acute peripheral vertigo in the emergency department: a randomized, double blind, clinical trial. Turk J Emerg Med 7(1):010–017Google Scholar
- 8.Motamed H, Moezzi M, Rooyfard AD, Angali KA, Izadi Z (2017) A comparison of the effects and side effects of oral betahistine with injectable promethazine in the treatment of acute peripheral vertigo in emergency. J Clin Med Res 9(12):994–997. https://doi.org/10.14740/jocmr3093w CrossRefPubMedPubMedCentralGoogle Scholar