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Interaction between paracetamol and lamotrigine: new insights from the FDA Adverse Event Reporting System (FAERS) database

  • Carla CarnovaleEmail author
  • Giulia Mosini
  • Michele Gringeri
  • Vera Battini
  • Faizan Mazhar
  • Marco Pozzi
  • Emilio Clementi
  • Sonia Radice
Letter to the Editor
  • 39 Downloads

Dear Editor,

Lamotrigine is considered a first-line treatment for epilepsy and bipolar disorder, because of its favourable tolerability profile. Therefore, it is extensively used in as fragile populations as elderly people and children [1]. Moreover, paracetamol is often co-administered with the anticonvulsant drug for its analgesic and antipyretic proprieties, since several interactions between lamotrigine and other NSAIDs (nonsteroidal anti-inflammatory drugs), such as aspirin, have been reported [2]. Administration of paracetamol was shown in two studies to decrease the t½ and increase the clearance of a single dose of lamotrigine, suggesting a possible drug-drug interaction (DDI) [2, 3]. Based on this limited evidence, contradictory practical recommendations on the clinical consequences of the concomitant use of lamotrigine and paracetamol have ensued [3] (https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020241s037s038,020764s030s031lbl.pdf; https://ca.gsk.com/media/529318/lamictal.pdf...

Notes

Acknowledgements

Faizan Mazhar is supported by the 33rd cycle Ph.D. programme in ‘Scienze Farmacologiche Sperimentali e Cliniche’, Università degli Studi di Milano.

Funding

This study was supported by the Centre of Pharmacovigilance of Regione Lombardia (MEAP project, Monitoraggio degli eventi avversi nelle popolazioni a rischio, to EC) and by the Italian Ministry of Health (RC 2018 to MP).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Carla Carnovale
    • 1
    Email author
  • Giulia Mosini
    • 1
  • Michele Gringeri
    • 1
  • Vera Battini
    • 1
  • Faizan Mazhar
    • 1
  • Marco Pozzi
    • 2
  • Emilio Clementi
    • 1
    • 2
  • Sonia Radice
    • 1
  1. 1.Unit Clinical Pharmacology, Department of Biomedical and Clinical SciencesUniversity Hospital “Luigi Sacco”-University of Milan ASST Fatebenefratelli-SaccoMilanItaly
  2. 2.Scientific Institute, IRCCS E. MedeaBosisio PariniItaly

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