Interaction between paracetamol and lamotrigine: new insights from the FDA Adverse Event Reporting System (FAERS) database
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Lamotrigine is considered a first-line treatment for epilepsy and bipolar disorder, because of its favourable tolerability profile. Therefore, it is extensively used in as fragile populations as elderly people and children . Moreover, paracetamol is often co-administered with the anticonvulsant drug for its analgesic and antipyretic proprieties, since several interactions between lamotrigine and other NSAIDs (nonsteroidal anti-inflammatory drugs), such as aspirin, have been reported . Administration of paracetamol was shown in two studies to decrease the t½ and increase the clearance of a single dose of lamotrigine, suggesting a possible drug-drug interaction (DDI) [2, 3]. Based on this limited evidence, contradictory practical recommendations on the clinical consequences of the concomitant use of lamotrigine and paracetamol have ensued  (https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020241s037s038,020764s030s031lbl.pdf; https://ca.gsk.com/media/529318/lamictal.pdf...
Faizan Mazhar is supported by the 33rd cycle Ph.D. programme in ‘Scienze Farmacologiche Sperimentali e Cliniche’, Università degli Studi di Milano.
This study was supported by the Centre of Pharmacovigilance of Regione Lombardia (MEAP project, Monitoraggio degli eventi avversi nelle popolazioni a rischio, to EC) and by the Italian Ministry of Health (RC 2018 to MP).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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