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Calcified Tissue International

, Volume 105, Issue 4, pp 373–382 | Cite as

The Local and Systemic Interactions Between Muscle and Bone in Postmenopausal Korean Women

  • Mi Kyung Kwak
  • Beom-Jun Kim
  • Jae Seung Kim
  • Seung Hun LeeEmail author
  • Jung-Min KohEmail author
Original Research

Abstract

Despite many studies about local and systemic interactions between bone and muscle, the more dominant interaction remains unclear. We aimed to compare the association of skeletal muscle mass with bone mineral density (BMD) at the femur, which seemed more likely affected by local interaction, and the association of skeletal muscle mass with BMD at the lumbar spine (LS-BMD) and the trabecular bone score (TBS), which seemed more likely affected by systemic interaction. In 279 women, we measured the femoral neck BMD (FN-BMD), total hip BMD (TH-BMD), LS-BMD, and TBS. Appendicular skeletal muscle mass (ASM), lean mass (LM), and other LM (OLM; remaining LM excluding ASM) were measured using bioelectrical impedance analysis. ASM (β = 0.008–0.014, p < 0.001–0.014), OLM (β = 0.006–0.011, p < 0.001–0.044), and LM (β = 0.004–0.007, p < 0.001–0.020) were positively associated with FN-BMD and TH-BMD, but not with LS-BMD or TBS. The positive association of ASM, but not of OLM, was stronger than that of LM (p = 0.023). Odd ratios (ORs) with 95% confidence intervals (95% CIs) for osteoporosis were statistically significant for ASM (OR 0.74, 95% CI 0.59–0.93) and marginally significant for OLM (OR 0.80, 95% CI 0.64–1.01) in the femur, but not in the LS. The direct and indirect (through OLM) effects of ASM on BMD were 69.1–72.2% and 27.8–30.9%, respectively. In the conclusion, ASM was more positively associated with FN-BMD, but not with LS-BMD and TBS, than OLM. This suggests stronger effects of local interaction than systemic interaction between muscle and bone.

Keywords

Bone Bone–muscle crosstalk Muscle Trabecular bone score 

Notes

Acknowledgements

This study was supported by Grants from the Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (Project No. HI15C2792).

Compliance with Ethical Standards

Conflict of interest

MK Kwak, B-J Kim, JS Kim, SH Lee, and J-M Koh declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

The study was approved by the institutional review board at Asan Medical Center (2018-0157), and all participants provided written informed consent.

Supplementary material

223_2019_585_MOESM1_ESM.tif (625 kb)
Supplementary material 1 (TIFF 625 kb). Fig. S1 Flowchart of patient inclusion in this study
223_2019_585_MOESM2_ESM.tif (296 kb)
Supplementary material 2 (TIFF 295 kb). Fig. S2 A model for explaining the relationship between appendicular skeletal muscle mass (ASM) and bone mineral density (BMD) at the femur, with other lean mass (OLM) except for ASM as a mediator. Model 1 assumes that ASM is directly associated with higher BMD by a coefficient of C. Model 2 considers that ASM affects other LM (represented by the coefficient A), which, in turn, affects BMD (represented by coefficient B). The direct effect (C′) was estimated using the product of coefficients A and B

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Endocrinology and Metabolism, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea
  2. 2.Division of Endocrinology and MetabolismHallym University Dongtan Sacred Heart HospitalHwaseong-siRepublic of Korea
  3. 3.Division of Nuclear Medicine, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea

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