Long-Term Stable Bone Mineral Density in HIV-Infected Men Without Risk Factors for Osteoporosis Treated with Antiretroviral Therapy
Most prospective studies of bone mineral density (BMD) in HIV-infected cohorts taking antiretroviral therapy (ART) have been of short duration, typically < 3 years. Such studies have reported short-term stable or increasing BMD. We assessed whether this BMD stability persists for > 10 years in middle-aged and older men established on ART.
A 12-year, prospective, longitudinal study in 44 HIV-infected men treated with ART who had measurements of BMD at the lumbar spine, proximal femur and total body at baseline, 2, 6 and 12 years.
At baseline, the mean age of participants was 49 years, the mean duration of HIV infection was 8 years, and the mean duration of ART was 50 months. After 12 years, BMD increased by 6.9% (95% CI 3.4 to 10.3) at the lumbar spine, and remained stable (range of BMD change: − 0.6% to 0.0%) at the total hip, femoral neck and total body. Only two individuals had a decrease of > 10% in BMD at any site during follow-up and both decreases in BMD were explained by co-morbid illnesses.
BMD remained stable over 12 years in middle-aged and older HIV-infected men treated with ART. Monitoring BMD in men established on ART who do not have risk factors for BMD loss is not necessary.
KeywordsHIV Bone density Osteopenia Osteoporosis Body weight
MB, AH, SB, MT, IR, GG and AG designed the study. MB drafted the manuscript and is the guarantor. MB and AH ran the study. MB and GG did the statistical analyses. All authors revised the paper critically for intellectual content and approved the final version. All authors agree to be accountable for the work and to ensure that any questions relating to the accuracy and integrity of the paper are investigated and properly resolved.
This study was funded by the Health Research Council of New Zealand.
Compliance with Ethical Standards
Conflict of interest
Mark Bolland, Anne Horne, Simon Briggs, Mark Thomas, Ian Reid, Greg Gamble and Andrew Grey declare that they have no conflicts of interest.
Human and Animal Rights and Informed Consent
The study received ethical approval from the Northern X Regional ethics committee, and all participants provided written, informed consent.
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