A highly fluorescent lanthanide metal-organic framework as dual-mode visual sensor for berberine hydrochloride and tetracycline

  • Jie Xiong
  • Lu Yang
  • Li Xia Gao
  • Pan Pan Zhu
  • Qian Chen
  • Ke Jun TanEmail author
Paper in Forefront


A microscale highly fluorescent Eu metal-organic framework (Eu-MOF) was synthesized with terephthalic acid and 1H-1,2,4-triazole-3,5-diamine by one-pot hydrothermal method. And it was characterized by scanning electron microscope, Fourier transform infrared spectroscopy, powder X-ray diffraction, fluorescence spectroscopy, thermogravimetric analysis, and energy dispersive X-ray mapping. The prepared Eu-MOF has high quantum yield of 30.99%, excellent water dispersibility, good fluorescence stability, and favorable thermal stability. Based on the distinctly different fluorescence responses of different emission, the prepared Eu-MOF was used as dual-mode visual sensor for the sensitive detection of berberine hydrochloride and tetracycline. The limits of detection are 78 nM and 17 nM, respectively. The sensing mechanism was also discussed. Moreover, a filter paper sensor has been designed for sensing tetracycline with a notable fluorescence color change from blue to red. The prepared Eu-MOF is promising to be developed as a multi-mode luminescent sensor for visual detection in biochemical analysis.

Graphical abstract

Illustration of the synthesis of Eu-MOF and its sensing applications for berberine hydrochloride and tetracycline


Metal-organic framework Dual-mode sensor Visual detection Berberine hydrochloride Tetracycline 


Funding information

This study received financial support from the National Natural Science Foundation of China (NSFC, No. 21377103).

Compliance with ethical standards

Ethical standards and informed consent

This work was approved by The Laboratory Animal Ethics Review Committee for Southwest University and was performed in accordance with ethical standards. Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

216_2019_2004_MOESM1_ESM.pdf (2.2 mb)
ESM 1 (PDF 2261 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Jie Xiong
    • 1
  • Lu Yang
    • 1
  • Li Xia Gao
    • 1
  • Pan Pan Zhu
    • 1
  • Qian Chen
    • 1
  • Ke Jun Tan
    • 1
    Email author
  1. 1.Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical EngineeringSouthwest UniversityChongqingChina

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