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Analytical and Bioanalytical Chemistry

, Volume 411, Issue 20, pp 5149–5157 | Cite as

Dopamine-functionalized cyclodextrins: modification of reduced graphene oxide based electrodes and sensing of folic acid in human serum

  • Fereshteh ChekinEmail author
  • Vladyslav Mishyn
  • Alexandre Barras
  • Joel Lyskawa
  • Ran Ye
  • Sorin Melinte
  • Patrice Woisel
  • Rabah Boukherroub
  • Sabine SzuneritsEmail author
Research Paper
  • 17 Downloads

Abstract

A mandatory step in any sensor fabrication is the introduction of analyte-specific recognition elements to the transducer surface. In this study, the possibility to anchor β-cyclodextrin-modified dopamine to a reduced graphene oxide based electrochemical transducer for the sensitive and selective sensing of folic acid is demonstrated. The sensor displays good electrocatalytic activity toward the oxidation of folic acid. The strong affinity of the surface-confined β-cyclodextrin for folic acid, together with favorable electron transfer characteristics, resulted in a sensor with a detection limit of 1 nM for folic acid and a linear response up to 10 μM. Testing of the sensor on serum samples from healthy individuals and patients diagnosed with folic acid deficiency validated the sensing capability.

Graphical abstract

Keywords

β-Cyclodextrin Reduced graphene oxide Electrophoretic deposition Folic acid Electrochemical sensor 

Notes

Acknowledgements

Financial support from the Centre National de la Recherche Scientifique, the University of Lille, the Hauts-de-France region, the CPER “Photonics for Society,” and the Agence Nationale de la Recherche through the FLAG-ERA JTC 2015-Graphtivity project is acknowledged. We are grateful to the Walloon Region for financial support in the frame of the "BATWAL" project - "Programme d'Excellence". Work at UCLouvain has been carried out within the project LUMINOPTEX (avec le soutien du Fonds Européen de Développement Régional / met steun van het Europees Fonds voor Regionale Ontwikkeling - INTERREG V France-Wallonie-Vlaanderen). The work was supported by the Belgian F.R.S. - FNRS in the frame of the research conventions no. R 50.02.16.F and no. T.0106.16.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

216_2019_1892_MOESM1_ESM.pdf (147 kb)
ESM 1 (PDF 146 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Fereshteh Chekin
    • 1
    • 2
    Email author
  • Vladyslav Mishyn
    • 2
  • Alexandre Barras
    • 2
  • Joel Lyskawa
    • 3
  • Ran Ye
    • 4
  • Sorin Melinte
    • 4
  • Patrice Woisel
    • 3
  • Rabah Boukherroub
    • 2
  • Sabine Szunerits
    • 2
    Email author
  1. 1.Department of Chemistry, Ayatollah Amoli BranchIslamic Azad UniversityAmolIran
  2. 2.Université de Lille, CNRS, Centrale Lille, ISENUniversité de ValenciennesLilleFrance
  3. 3.Unité des Matériaux et Transformations (UMR 8207), Equipe Ingénierie des Systèmes PolymèresUniversité de LilleVilleneuve d’Ascq CedexFrance
  4. 4.Institute of Information and Communication Technologies, Electronics and Applied MathematicsUniversité catholique de LouvainLouvain-la-NeuveBelgium

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