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Analytical and Bioanalytical Chemistry

, Volume 411, Issue 12, pp 2475–2479 | Cite as

The 2018 Nobel Prize in Chemistry: phage display of peptides and antibodies

  • Rodrigo BarderasEmail author
  • Elena Benito-PeñaEmail author
Feature Article

Abstract

One-half of the 2018 Nobel Prize in Chemistry was awarded jointly to George P. Smith and Sir Gregory P. Winter “for the phage display of peptides and antibodies”. This feature article summarizes significant achievements leading to the development of phage display of peptides and antibodies, where a bacteriophage is genetically modified to display peptides and proteins, with the primary aim of producing new biopharmaceuticals. These significant achievements are proven to be useful for the development of phage-based bioassays and biosensors.

Keywords

Nobel Prize 2018 Phage display of peptides and proteins Biopharmaceuticals Therapeutic antibodies 

Notes

Funding information

R.B. and E. B-P. acknowledge financial support from the PI17CIII/00045 grant from the AES-ISCIII program and the CTQ2015-69278-C2-1-R/AIE grant from the Ministry of Economy and Competitiveness (MINECO), respectively.

Compliance with ethical standards

The authors declare that there are no conflicts of interest regarding this manuscript.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Functional Proteomics Unit, UFIEC, Chronic Disease ProgrammeInstituto de Salud Carlos IIIMadridSpain
  2. 2.Departamento de Química Analítica, Facultad de Ciencias QuímicasUniversidad Complutense de MadridMadridSpain

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