Development of a low-cost electrochemical sensor based on babassu mesocarp (Orbignya phalerata) immobilized on a flexible gold electrode for applications in sensors for 5-fluorouracil chemotherapeutics
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There are increasing concerns regarding the risks arising from the contamination of manipulators of antineoplastic drugs promoted by occupational exposure or even in the dosage of drugs. The present work proposes the use of an electrochemical sensor based on a biopolymer extracted from the babassu coconut (Orbignya phalerata) for the determination of an antineoplastic 5-fluorouracil (5-FU) drug as an alternative for the monitoring of these drugs. In order to reduce the cost of this sensor, a flexible gold electrode (FEAu) is proposed. The surface modification of FEAu was performed with the deposition of a casting film of the biopolymer extracted from the babassu mesocarp (BM) and modified with phthalic anhydride (BMPA). The electrochemical activity of the modified electrode was characterized by cyclic voltammetry (CV), and its morphology was observed by atomic force microscopy (AFM). The FEAu/BMPA showed a high sensitivity (8.8 μA/μmol/L) and low limit of detection (0.34 μmol/L) for the 5-FU drug in an acid medium. Electrochemical sensors developed from the babassu mesocarp may be a viable alternative for the monitoring of the 5-FU antineoplastic in pharmaceutical formulations, because in addition to being sensitive to this drug, they are constructed of a natural polymer, renewable, and abundant in nature.
KeywordsBabassu mesocarp Flexible gold electrode Sensor 5-Fluorouracil Electrochemistry
The authors would like to thank the Federal University of Piauí (UFPI) and Federal Institute of Piauí (IFPI) for providing the research and work facilities.
This study received financial supports from the Coordination for the Improvement of Higher Education Personnel CAPES (Financing Code 001), National Council for Scientific and Technological Development (CNPq), and Foundation for Research Support of Piauí (FAPEPI).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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