Analytical and Bioanalytical Chemistry

, Volume 411, Issue 1, pp 171–179 | Cite as

An ultrasensitive sensor based on quantitatively modified upconversion particles for trace bisphenol A detection

  • Qiaofeng Li
  • Jialei Bai
  • Shuyue Ren
  • Jiang Wang
  • Yifei Gao
  • Shuang Li
  • Yuan Peng
  • Baoan NingEmail author
  • Zhixian GaoEmail author
Research Paper


Bisphenol A (BPA) is one of the endocrine-disrupting chemicals which might cause reproductive and endocrine system diseases, and poses a serious threat to the ecosystem and human health. This paper reports an ultrasensitive sensor for trace BPA detection employing fluorescence resonance energy transfer (FRET) between modified upconversion nanoparticles (UCNPs) and tetramethylrhodamine. To circumvent the problems of low luminous efficiency of FRET and low sensitivity of sensor, the upconversion nanoparticles with very strong fluorescence efficiency were prepared and quantitatively modified. Results showed that the concentrations of amino groups and streptavidin were 43 nmol/mg and 6.12 μg/mg on the surface of the UCNPs, respectively. Under the optimal detection conditions, the peak intensity of UCNPs at 547 nm was linear with the logarithm of the BPA concentration with the detection limit of 0.05 ng/mL. Without complicated pre-processing, the recoveries were in general between 91.0 and 115.0% in tap water, river water, and disposable paper cup water. Therefore, the proposed sensor is suitable for effective sensing of trace BPA in water samples.

Graphical abstract


Sensor Upconversion particles Quantitative modification Bisphenol A 


Funding information

This work was supported by the National Natural Science Foundation of China (Grant Nos. 21477162, 81602896, AWS15J006); the Tianjin Research Program of Application Foundation and Advanced Technology (Grant No. 15JCYBJC51200); the National Key Research and Development Program of China (Grant No. 2017YFF0104903) and Natural Science Fund of Tianjin City (Grant No. 17JCQNJC12500).

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no competing interest.

Supplementary material

216_2018_1425_MOESM1_ESM.pdf (5.8 mb)
ESM 1 (PDF 5869 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Qiaofeng Li
    • 1
    • 2
  • Jialei Bai
    • 1
  • Shuyue Ren
    • 1
  • Jiang Wang
    • 1
  • Yifei Gao
    • 3
  • Shuang Li
    • 1
  • Yuan Peng
    • 1
  • Baoan Ning
    • 1
    Email author
  • Zhixian Gao
    • 1
    Email author
  1. 1.Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Institute of Environmental and Operational MedicineAcademy of Military Medical Science, Academy of Military ScienceTianjinChina
  2. 2.State Key Laboratory of Food Science and TechnologySchool of Food Science and TechnologyWuxiChina
  3. 3.School of ChemistryUniversity of New South WalesSydneyAustralia

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