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Analytical and Bioanalytical Chemistry

, Volume 411, Issue 3, pp 591–602 | Cite as

Skip the beat: minimizing aliasing error in LA-ICP-MS measurements

  • Bodo HattendorfEmail author
  • Urs Hartfelder
  • Detlef Günther
Research Paper
Part of the following topical collections:
  1. Elemental and Molecular Imaging by LA-ICP-MS

Abstract

Pulsed laser ablation sampling and sequential isotope detection can lead to signal beat in the registered signal intensities. In particular, if aerosol transport systems deliver ablated aerosol with temporal duration close to that of a single mass scan, such signal beat can become significant and lead to biased intensity ratios and concentrations. Averaging signal intensities based on the least common multiple of scan duration and laser pulse period can eliminate such a systematic bias and improve the accuracy of quantitative laser ablation experiments. The method was investigated for experiments using an ablation cell that provided aerosol washout times near 200 ms and quadrupole-based ICP-MS acquisition using different dwell and settling times that were compared with and extended by numerical simulations. It was found that the systematic bias of acquired data could exceed the inherent noise of laser ablation inductively couple plasma mass spectrometry experiments and that the averaging method could successfully minimize the bias due to beating. However, simulations revealed that this was only the case for combinations of pulse frequency and scan duration in which the number of laser pulses within the averaged period was an integer multiple of the number of isotopes in the acquisition method. In element imaging applications, this averaging will necessarily increase the size of individual pixels and it depends not only on the laser beam size but also pulse repetition rate and the acquisition settings for a sequential mass spectrometer.

Graphical abstract

LCM averaging can prevent occurrence of a systematic bias in LA-ICPMS measurements

Keywords

Accuracy Aliasing Imaging LA-ICP-MS Sequential detection Spectral skew 

Notes

Acknowledgements

Roland Mäder is very much thanked for designing and manufacturing the ablation cell that made the experiments possible.

Funding information

This work was made possible by funding from the ETH Zurich.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

216_2018_1314_MOESM1_ESM.pdf (5 kb)
ESM 1 (PDF 4 kb)
216_2018_1314_MOESM2_ESM.xlsx (91 kb)
ESM 2 (XLSX 90 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Bodo Hattendorf
    • 1
    Email author
  • Urs Hartfelder
    • 2
  • Detlef Günther
    • 1
  1. 1.Laboratory of Inorganic ChemistryZurichSwitzerland
  2. 2.Büchi Labortechnik AGFlawilSwitzerland

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