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i-Motif DNA structures upon electric field exposure: completing the map of induced genetic errors

  • José P. Cerón-CarrascoEmail author
  • Denis Jacquemin
Regular Article

Abstract

The architecture of DNA is not exclusively assembled with a sequence of Watson–Crick guanine–cytosine (GC) and adenine–thymine (AT) base pairs. On the contrary, recent experiments have detected G-quadruplex structures in G-islands, whereas C-rich regions are organized as intercalated motif (i-motif) structures. In the latter, several hemiprotonated–cytosine dimers are inserted in a large repetitive series. Previous computational characterizations of the impact of external electric fields on DNA’s mutations were focused on understanding GC, AT and G-quadruplex species. The present work provides a first assessment of the influence of intense fields onto the structure of i-motifs with the aim of reaching a more accurate prediction of the stability of DNA under the exposure of physics agents. The performed calculations demonstrate that i-motifs are particularly sensitive to the applied fields.

Keywords

DNA Telomeres Mutation Proton transfer Density functional calculations 

Notes

Acknowledgements

This research used resources of CCIPL (Centre de Calcul Intensif des Pays de Loire) and Plataforma Andaluza de Bioinformática installed at the Universidad of Málaga, Spain.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Bioinformatics and High Performance Computing Research Group (BIO-HPC)Universidad Católica San Antonio de Murcia (UCAM)MurciaSpain
  2. 2.CEISAM UMR CNRS 6230Université de NantesNantesFrance
  3. 3.Institut Universitaire de FranceParisFrance

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