Ayahuasca’s ‘afterglow’: improved mindfulness and cognitive flexibility in ayahuasca drinkers
There is a growing body of evidence demonstrating the therapeutic potential of ayahuasca for treating depression and anxiety. However, the mechanisms of action involved in ayahuasca’s therapeutic effects are unclear. Mindfulness and cognitive flexibility may be two possible psychological mechanisms. Like other classic psychedelics, ayahuasca also leads to an ‘afterglow’ effect of improved subjective well-being that persists after the acute effects have subsided. This period may offer a window of increased therapeutic potential.
To explore changes in mindfulness and cognitive flexibility before and within 24 h after ayahuasca use.
Forty-eight participants (54% female) were assessed on measures of mindfulness (Five Facets Mindfulness Questionnaire (FFMQ)), decentering (Experiences Questionnaire (EQ)), and cognitive flexibility (Cognitive Flexibility Scale (CFS)), and completed the Stroop and Wisconsin Picture Card Sorting Task (WPCST) before drinking ayahuasca, and again within 24 h.
Mindfulness (FFMQ total scores and four of the five mindfulness facets: observe, describe, act with awareness, and non-reactivity) and decentering (EQ) significantly increased in the 24 h after ayahuasca use. Cognitive flexibility (CFS and WPCST) significantly improved in the 24 h after ayahuasca use. Changes in both mindfulness and cognitive flexibility were not influenced by prior ayahuasca use.
The present study supports ayahuasca’s ability to enhance mindfulness and further reports changes in cognitive flexibility in the ‘afterglow’ period occur, suggesting both could be possible psychological mechanisms concerning the psychotherapeutic effects of ayahuasca. Given psychological gains occurred regardless of prior ayahuasca use suggests potentially therapeutic effects for both naïve and experienced ayahuasca drinkers.
KeywordsAyahuasca Psychedelics Mindfulness Cognitive flexibility Psychological flexibility Psychological mechanisms
This study was funded by internal UEL funds only.
Compliance with ethical standards
The study was granted ethical approval by the School of Psychology, University of East London’s Ethics Committee.
Conflict of interest
The authors declare that they have no conflict of interest.
- Alonso JF, Romero S, Mañanas MÀ, Riba J (2015) Serotonergic psychedelics temporarily modify information transfer in humans. Int J Neuropsychopharmacol 18(8). https://doi.org/10.1093/ijnp/pyv039
- Carhart-Harris RL, Leech R, Hellyer PJ, Shanahan M, Feilding A, Tagliazucchi E, Nutt D (2014) The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs. Front Hum Neurosci:8Google Scholar
- Gossop, M. (1995). Severity of Dependence Scale. PsycTESTS DatasetGoogle Scholar
- Gouzoulis-Mayfrank E, Thelen B, Habermeyer E, Kunert HJ, Kovar K, Lindenblatt H et al (1999) Psychopathological, neuroendocrine and autonomic effects of 3,4-methylenedioxyethylamphetamine (MDE), psilocybin and d -methamphetamine in healthy volunteers. Psychopharmacology 142(1):41–50CrossRefGoogle Scholar
- Griffiths RR, Johnson MW, Carducci MA, Umbricht A, Richards WA, Richards BD, Cosimano MP, Klinedinst MA (2016) Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: a randomized double blind trial. J Psychopharmacol 30(12):1181–1197CrossRefGoogle Scholar
- Heaton RK (1981) A manual for the Wisconsin Card Sorting Test. Western Psychological Services, Los AngelesGoogle Scholar
- Hermle L, Fünfgeld M, Oepen G, Botsch H, Borchardt D, Gouzoulis E, Spitzer M (1992) Mescaline induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: experimental psychosis as a tool for psychiatric research. Biol Psychiatry 32(11):976–991CrossRefGoogle Scholar
- Martin, M. M., & Rubin, R. B. (1995). A new measure of cognitive flexibility. Psychological Reports, 76(2):Google Scholar
- Prickett JI, Liester MB (2002) Hypotheses regarding ayahuasca’s potential mechanisms of action in the treatment of addiction. In: Labate B, Canvar C (eds) The therapeutic use of ayahuasca. Springer, Berlin, pp 111–132Google Scholar
- Sampedro F, De la Fuente Revenga M, Valle M, Roberto N, Domínguez-Clavé E, Elices M, Riba J (2017) Assessing the psychedelic “after-glow” in ayahuasca users: post-acute neurometabolic and functional connectivity changes are associated with enhanced mindfulness capacities. Int J Neuropsychopharmacol 20(9):698–711CrossRefGoogle Scholar
- Soler J, Elices M, Dominguez-Clavé E, Pascual JC, Feilding A, Navarro-Gil M, Riba J (2018) Four weekly ayahuasca sessions lead to increases in “acceptance” capacities: a comparison study with a standard 8-week mindfulness training program. Front Pharmacol 9Google Scholar
- Stroop, J. R. (1935). Stroop Color Interference Test. PsycTESTS DatasetGoogle Scholar