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Psychopharmacology

, Volume 236, Issue 7, pp 2287–2289 | Cite as

Acquired synaesthesia following 2C-B use

  • Steliana Yanakieva
  • David P. Luke
  • Ashok Jansari
  • Devin B. TerhuneEmail author
Letter to the Editor

Psychedelic drugs reliably trigger experiences that closely resemble synaesthesia (Luke and Terhune 2013), a condition in which inducer stimuli will reliably and automatically elicit atypical concurrent experiences (Ward 2013). These transient episodes are considered controversial because they do not meet behavioural diagnostic criteria for developmental synaesthesia (Terhune et al. 2016). However, if these behavioural markers are attributable to the consolidation of synaesthetic associations over time (Terhune et al. 2016), they should be observed in cases of acquired synaesthesia. Here we report a case of drug-induced acquired synaesthesia (LW) that meets standard diagnostic criteria for developmental synaesthesia.

LW is a 29-year-old male who reports continuously experiencing multiple forms of synaesthesia for over 7 years since ingesting approximately 70–150 mg of 2,5-dimethoxy-4-bromophenethylamine (2C-B) (Papaseit et al. 2018), which greatly exceeds the normal dosage (12–24 mg)...

Notes

Authors’ contribution

SY: study concept and design, data acquisition, analysis and interpretation of data, and drafting/revising the manuscript. DPL: study concept and design, data interpretation, and revising the manuscript. AJ: study concept and design, data interpretation, and revising the manuscript. DBT: study concept and design, data acquisition, analysis and interpretation of data, and drafting/revising the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interests.

Supplementary material

213_2019_5242_MOESM1_ESM.docx (115 kb)
ESM 1 (DOCX 114 kb)

References

  1. Brogaard B, Gatzia DE (2016) Psilocybin, LSD, mescaline and drug-induced synesthesia. In: Preedy VR (ed) Neuropathology of drug addictions and substance misuse. Academic Press, Elsevier, Amsterdam, NL, pp 890–905CrossRefGoogle Scholar
  2. Dixon MJ, Smilek D, Merikle PM (2004) Not all synaesthetes are created equal: projector versus associator synaesthetes. Cogn Affect Behav Neurosci 4:335–343CrossRefGoogle Scholar
  3. Eagleman DM, Kagan AD, Nelson SS, Sagaram D, Sarma AK (2007) A standardized test battery for the study of synesthesia. J Neurosci Methods 159:139–145CrossRefGoogle Scholar
  4. Litjens RP, Brunt TM, Alderliefste GJ, Westerink RH (2014) Hallucinogen persisting perception disorder and the serotonergic system: a comprehensive review including new MDMA-related clinical cases. Eur Neuropsychopharmacol 24:1309–1323CrossRefGoogle Scholar
  5. Luke DP, Terhune DB (2013) The induction of synaesthesia with chemical agents: a systematic review. Front Psychol 4:753Google Scholar
  6. Luke D, Terhune D, Friday R (2012) Psychedelic synaesthesia: evidence for a serotonergic role in synaesthesia. Seeing Perceiving 25:74CrossRefGoogle Scholar
  7. Martinotti G, Santacroce R, Pettorruso M, Montemitro C, Spano MC, Lorusso M, di Giannantonio M, Lerner AG (2018) Hallucinogen persisting perception disorder: etiology, clinical features, and therapeutic perspectives. Brain Sci 8Google Scholar
  8. Páleníček T, Fujáková M, Brunovský M, Horáček J, Gorman I, Balíková M, Rambousek L, Syslová K, Kačer P, Zach P, Bubeníková-Valešová V, Tylš F, Kubešová A, Puskarčíková J, Höschl C (2013) Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats. Psychopharmacology 225:75–93CrossRefGoogle Scholar
  9. Papaseit E, Farre M, Perez-Mana C, Torrens M, Ventura M, Pujadas M, de la Torre R, Gonzalez D (2018) Acute pharmacological effects of 2C-B in humans: an observational study. Front Pharmacol 9:206CrossRefGoogle Scholar
  10. Rothen N, Meier B (2014) Acquiring synaesthesia: insights from training studies. Front Hum Neurosci 8:109CrossRefGoogle Scholar
  11. Rothen N, Seth AK, Witzel C, Ward J (2013) Diagnosing synaesthesia with online colour pickers: maximising sensitivity and specificity. J Neurosci Methods 215:156–160CrossRefGoogle Scholar
  12. Shulgin A, Shulgin A (1990) PIHKAL: a chemical love story. Transform Press, Berkeley, CAGoogle Scholar
  13. Skelton R, Ludwig C, Mohr C (2009) A novel, illustrated questionnaire to distinguish projector and associator synaesthetes. Cortex 45:721–729CrossRefGoogle Scholar
  14. Terhune DB, Tai S, Cowey A, Popescu T, Cohen Kadosh R (2011) Enhanced cortical excitability in grapheme-color synesthesia and its modulation. Curr Biol 21:2006–2009CrossRefGoogle Scholar
  15. Terhune DB, Murray E, Near J, Stagg CJ, Cowey A, Cohen Kadosh R (2015) Phosphene perception relates to visual cortex glutamate levels and covaries with atypical visuospatial awareness. Cereb Cortex 25:4341–4350CrossRefGoogle Scholar
  16. Terhune DB, Luke DP, Kaelen M, Bolstridge M, Feilding A, Nutt D, Carhart-Harris R, Ward J (2016) A placebo-controlled investigation of synaesthesia-like experiences under LSD. Neuropsychologia 88:28–34CrossRefGoogle Scholar
  17. Ward J (2013) Synesthesia. Annu Rev Psychol 64:49–75CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of PsychologyGoldsmiths, University of LondonLondonUK
  2. 2.Department of Psychology, Social Work and CounsellingUniversity of GreenwichLondonUK

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