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Psychopharmacology

, Volume 236, Issue 8, pp 2513–2525 | Cite as

Avoid-approach conflict behaviors differentially affected by anxiolytics: implications for a computational model of risky decision-making

  • Cody J. Walters
  • Jerrius Jubran
  • Ayaka Sheehan
  • Matthew T. Erickson
  • A. David RedishEmail author
Original Investigation

Abstract

Whether fear or anxiety is expressed is thought to depend on an animal’s proximity to threat. In general, fear is elicited when threat is proximal, while anxiety is a response to threat that is distal and uncertain. This threat gradient model suggests that fear and anxiety involve non-overlapping neural circuitry, yet few behavioral paradigms exist that elicit both states. We studied avoid-approach conflict in rats that were behaving in a predator-inhabited foraging arena task that involved tangible threat and reward incentives. In the task, rats exhibited a variety of both fearful and anxious behaviors corresponding to proximal and distal threat, respectively. We then administered ethanol or diazepam to the rats in order to study how anxiolytics affected these fear and anxiety behaviors. We discovered that both ethanol and diazepam attenuated proximal-threat fear-like behaviors. Furthermore, we found that diazepam, but not ethanol, increased distal-threat anxiety-like behavior but also made rats less risk-averse. Finally, we describe how decisional conflict can be modeled as a partially observable Markov decision process and characterize a potential relationship between anxious behavior, diazepam’s ability to suppress hippocampal theta oscillations, and hippocampal representations of the future.

Keywords

Decision-making Anxiety Fear Diazepam Ethanol Anxiolytics Avoid-approach conflict Foraging theory Prospection Computational modeling 

Notes

Acknowledgments

We are grateful to Brendan Hasz, Chris Boldt, and Kelsey Seeland for their technical assistance.

Funding

This work was supported by the National Institute on Drug Abuse Grants 4T32DA007234-30 and 2T32DA007234-31.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Graduate Program in NeuroscienceUniversity of MinnesotaMinneapolisUSA
  2. 2.University of MinnesotaMinneapolisUSA
  3. 3.St. Olaf CollegeNorthfieldUSA
  4. 4.Department of NeuroscienceUniversity of MinnesotaMinneapolisUSA

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