Effects of methamphetamine on neural responses to visual stimuli
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The behavioral and reward-related effects of stimulant drugs have been studied extensively; yet the effect of stimulants on sensory processing is still relatively unknown. Prior brain imaging studies have shown that single doses of stimulant drugs increase neural function during cognitive and attentional processes. However, it is not clear if stimulant drugs such as methamphetamine (MA) affect neural responses to novel sensory stimuli, and whether these effects depend on the visual features of the stimuli.
In this study, we examined the effects of a single dose of MA (20 mg oral) on neural activation in response to visual stimuli that varied on “non-straight edges” (NSE), a low-level visual feature that quantifies curved/fragmented edges and is related to perceived image complexity.
Healthy adult participants (n = 18) completed two sessions in which they received MA and placebo in counterbalanced order before an fMRI scan where they viewed both high and low NSE images. Participants also completed measures of subjective drug effects throughout both sessions.
During both sessions, high NSE images activated primary visual cortex to a greater extent than low NSE images. Further, MA increased activation only for low NSE images in three areas of visual association cortex: left fusiform, right cingulate/precuneus, and posterior right middle temporal gyrus. This interaction was unrelated to subjective drug effects.
These findings suggest that stimulant drugs may change the relative sensitivity of higher order sensory processing to increase visual attention when viewing less complex stimuli. Moreover, MA-induced alterations in this type of sensory processing appear to be independent of the drugs’ ability to increase feelings of well-being.
KeywordsMethamphetamine fMRI Visual features Environmental stimuli
This research is financially supported by National Institute on Drug Abuse Grant R01 DA037011 (HdW), and benefitted from S10OD018448 awarded to the University of Chicago MRI Research Center. KVH was supported by National Institute of Mental Health training grant T32MH020065. MGB was partially supported by a National Science Foundation Grant (NSF-BCS-1632445), and KES was partially supported by a NSF Graduate Research Fellowship. The funding agencies had no involvement in the research other than financial support.
- APA (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Washington, DCGoogle Scholar
- Berman MG, Hout MC, Kardan O, Hunter MR, Yourganov G, Henderson JM, Hanayik T, Karimi H, Jonides J (2014) The perception of naturalness correlates with low-level visual features of environmental scenes. PLoS One 9(12):e114572. https://doi.org/10.1371/journal.pone.0114572 CrossRefPubMedPubMedCentralGoogle Scholar
- Eagle DM, Tufft MRA, Goodchild HL, Robbins TW (2007) Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol. Psychopharmacology 192(2):193–206. https://doi.org/10.1007/s00213-007-0701-7 CrossRefPubMedGoogle Scholar
- Jonkman LM, Kemner C, Verbaten MN, Koelega HS, Camfferman G, vd Gaag R J, …, van Engeland H (1997) Effects of methylphenidate on event-related potentials and performance of attention-deficit hyperactivity disorder children in auditory and visual selective attention tasks. Biol Psychiatry, 41(6):690–702Google Scholar
- Kardan O, Demiralp E, Hout MC, Hunter MR, Karimi H, Hanayik T, Yourganov G, Jonides J, Berman MG (2015) Is the preference of natural versus man-made scenes driven by bottom–up processing of the visual features of nature? Front Psychol 6(471). https://doi.org/10.3389/fpsyg.2015.00471
- Schmidt A, Müller F, Dolder PC, Schmid Y, Zanchi D, Liechti ME, Borgwardt S (2017) Comparative effects of methylphenidate, modafinil, and MDMA on response inhibition neural networks in healthy subjects. Int J Neuropsychopharmacol 20(9):712–720. https://doi.org/10.1093/ijnp/pyx037 CrossRefPubMedPubMedCentralGoogle Scholar
- Volkow ND, Wang G-J, Fowler JS, Telang F, Maynard L, Logan J, Gatley SJ, Pappas N, Wong C, Vaska P, Zhu W, Swanson JM (2004) Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain. Am J Psychiatr 161(7):1173–1180. https://doi.org/10.1176/appi.ajp.161.7.1173 CrossRefPubMedGoogle Scholar