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Psychopharmacology

, Volume 236, Issue 1, pp 407–414 | Cite as

The emerging neuroscience of appetitive and drug cue extinction in humans

  • Anna B. KonovaEmail author
  • Rita Z. GoldsteinEmail author
Commentary
  • 125 Downloads

Abstract

Fear extinction has been extensively studied in both humans and non-human animals, and this work has contributed greatly to our understanding and treatment of anxiety disorders. Yet other psychopathologies like addiction might be associated with impairments selectively in extinction of non-fear based, appetitive and drug cue associations, and these processes have been underexplored in clinical translational neuroscience. Important questions regarding similarities and differences in the neurobiological mechanisms underlying aversive and appetitive extinction remain unanswered, particularly those pertaining to cross-species evidence for the role of the ventromedial prefrontal cortex and, to some extent, the striatum. Here, we aim to draw attention to the paucity of studies investigating non-fear based extinction in humans, summarize emerging findings from the available literature, and highlight important directions for future research. We argue that closing these gaps in our understanding could help inform the development of more targeted, and perhaps more durable, forms of extinction-based treatments for addiction and related psychopathologies characterized by abnormally persistent appetitive and drug cue associations.

Notes

Funding information

The authors were supported by grants from the National Institute on Drug Abuse (F32DA039648 to A.B.K. and R01DA041528 and R21DA020626 to R.Z.G.).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Psychiatry and University Behavioral Health Care (UBHC)Rutgers University–New BrunswickPiscatawayUSA
  2. 2.Departments of Psychiatry and NeuroscienceIcahn School of Medicine at Mount Sinai, The Leon and Norma Hess Center for Science and MedicineNew YorkUSA

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