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Psychopharmacology

, Volume 235, Issue 8, pp 2267–2274 | Cite as

Decreased plasma levels of gasotransmitter hydrogen sulfide in patients with schizophrenia: correlation with psychopathology and cognition

  • Jian-wen Xiong
  • Bo Wei
  • Yan-kun Li
  • Jin-qiong Zhan
  • Shu-zhen Jiang
  • Hai-bo Chen
  • Kun Yan
  • Bin Yu
  • Yuan-jian Yang
Original Investigation

Abstract

Objective

Aberrant N-methyl-d-aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. Hydrogen sulfide (H2S) is an endogenous gasotransmitter that regulates NMDAR function. The current study investigated the relationship between plasma H2S levels and both psychopathological and cognitive symptoms in schizophrenia.

Materials and methods

Forty-one patients with schizophrenia and 40 healthy control subjects were recruited in present study. Schizophrenic symptomatology was assessed using the Positive and Negative Syndrome Scale (PANSS). Cognitive function was evaluated with a neuropsychological battery including seven neurocognitive tests. Plasma H2S levels were measured by reversed-phase high-performance liquid chromatography (RP-HPLC).

Results

Patients with schizophrenia performed worse in all of the cognitive tests than the healthy controls except for the visual memory. Plasma H2S levels were significantly lower in patients with schizophrenia relative to healthy control subjects (F = 3.821, p = 0.007). Correlation analysis revealed a significant negative correlation between the H2S levels and the PANSS general scores (r = − 0.413, p = 0.007). Additionally, a positive association was observed between plasma H2S levels and working memory (r = 0.416, p = 0.007), visual memory (r = 0.363, p = 0.020), or executive function (r = 0.344, p = 0.028) in patients. Partial correlation analysis showed that the correlations between the H2S levels and the PANSS general scores, working memory, visual memory, or executive function were still significant when controlling for age, gender, years of education, BMI, duration of illness, and age of onset.

Conclusion

The significant relations observed in the current study between H2S and the general psychopathological as well as cognitive symptoms suggest that decreased H2S is involved in the psychopathology and cognitive deficits of schizophrenia, and it might be a promising peripheral biomarker of schizophrenia.

Keywords

Schizophrenia Hydrogen sulfide Psychopathology Cognition 

Notes

Contribution

Jian-wen Xiong, Bo Wei, Yan-kun Li, Shu-zhen Jiang, Jin-qiong Zhan, Hai-bo Chen, and Kun Yan were responsible for the clinical data collection and lab experiments. Yuan-jian Yang and Bin Yu were responsible for the study design, statistical analysis, and manuscript preparation. All authors have contributed to and have approved the final manuscript.

Funding information

This study was supported by grants from the National Natural Science Foundation of China (No. 81560232, 81600939 and 81760254), the Natural Science Foundation of Jiangxi Province of China (No. 20151BBG70110 and 20161BAB205193), and the Natural Science Foundation of Hubei Province of China (No. 2014CFB186).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PsychiatryJiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang UniversityNanchangPeople’s Republic of China
  2. 2.Department of Pharmacology, School of PharmacyHubei University of Science and TechnologyXianningPeople’s Republic of China
  3. 3.Medical Experimental CenterJiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang UniversityNanchangPeople’s Republic of China
  4. 4.Department of PharmacyJiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang UniversityNanchangPeople’s Republic of China

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