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Psychopharmacology

, Volume 234, Issue 9–10, pp 1347–1355 | Cite as

From bench to bedside: mGluR2 positive allosteric modulators as medications to treat substance use disorders

  • Jane B. Acri
  • Alan J. Cross
  • Phil Skolnick
Review

Abstract

Objective

This paper provides an overview of the role of type 2 metabotropic glutamate receptors (mGluR2) in addiction and behaviors reflecting addictive processes.

Results

AZD8529, an mGluR2 positive allosteric modulator (PAM), failed to separate from placebo in a phase II schizophrenia trial. The demonstration by Athina Markou’s laboratory that AZD8529 attenuated both nicotine self-administration and cue-induced reinstatement was a key factor in the decision to move this compound into a smoking cessation study.

Conclusion

Here, we highlight Markou laboratory’s contribution to this project, as well as several innovative features of the phase II clinical trial that has already completed enrollment with top line results expected in early 2017.

Keywords

Athina Markou mGluR2 Cocaine Nicotine Glutamate Self-administration Cue-induced reinstatement Animal models Smoking cessation 

Notes

Compliance with Ethical Standards

Conflicts of interest

JBA and PS are employees of the US Government and have no conflicts of interest. AJC is an employee of AstraZeneca.

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Copyright information

© Springer-Verlag Berlin Heidelberg (outside the USA) 2016

Authors and Affiliations

  1. 1.Division of Therapeutics and Medical ConsequencesNational Institute on Drug AbuseBethesdaUSA
  2. 2.AstraZeneca Neuroscience Innovative Medicines and Early Development Biotech UnitCambridgeUSA

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