Several emerging lines of evidence support an anti-inflammatory role for nicotinic acid (niacin); however, its role in the regulation of leukocyte migration in response to inflammatory stimuli has not been elucidated until now. Herein, we have examined the effect of nicotinic acid on neutrophil recruitment in experimentally induced inflammation. We demonstrated that nicotinic acid treatment inhibited interleukin (IL)-8-induced, leukotriene (LT)B4-induced, and carrageenan-induced neutrophil migration into the pleural cavity of BALB/c mice and reduced neutrophil rolling and adherence in a mouse cremaster muscle preparation. Surprisingly, nicotinic acid treatment increased the level of the neutrophil chemoattractant KC in response to carrageenan. These results suggest that nicotinic acid plays an important role in the regulation of inflammation due to its ability to inhibit the actions of the neutrophil chemoattractants IL-8 and LTB4. Further inhibition of chemoattractants leads to impairment of leukocyte rolling and adherence to the vascular endothelium in the microcirculation of inflamed tissues.
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This work was supported by Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG) and Conselho Nacional de Pesquisa e Desenvolvimento (CNPq), Brazil. The authors are grateful to W.G. Pimenta for his excellent technical assistance. R.G.F., A.M.G., and L.F.G. are graduate student fellows from CAPES, Brazil.
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The authors declare they have no conflict of interest.
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Ferreira, R.G., Matsui, T.C., Gomides, L.F. et al. Niacin inhibits carrageenan-induced neutrophil migration in mice. Naunyn-Schmiedeberg's Arch Pharmacol 386, 533–540 (2013). https://doi.org/10.1007/s00210-013-0854-3
- Inflammatory response
- Neutrophil recruitment
- Nicotinic acid