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Comparison of proinflammatory potential of needle-shaped materials: aragonite and potassium titanate whisker

  • Masanori HorieEmail author
  • Yosuke Tabei
  • Sakiko Sugino
  • Kenichiro Eguchi
  • Ryo Chiba
  • Masahiko Tajika
Inorganic Compounds
  • 49 Downloads

Abstract

Among the crystal forms of calcium carbonate, aragonite has needle-like shape. Although materials with needle-shaped crystals are associated with pulmonary toxicity, the toxic activity of aragonite is unclear. Therefore, proinflammatory potential of aragonite, neutralized aragonite and potassium titanate whisker was evaluated. The cellular effects of aragonite were weaker than those of potassium titanate whisker. Aragonite treatment induced the expression of chemokines in A549 cells and macrophages. Although aragonite exhibited proinflammatory effects in vitro, pulmonary inflammation was not observed in vivo after intratracheal administration of aragonite in mice. We did not observe the induction of inflammatory cytokine secretion or tissue lesion in the lungs of mice after administration of aragonite. Potassium titanate whisker treatment induced chemokine secretion in vitro. An increase in the number of neutrophils was observed in the mice lung tissue after administration of potassium titanate whisker. Aragonite and neutralized aragonite both induced an increase in the levels of intracellular calcium, but the levels were significantly higher in cells treated with aragonite than in cells treated with neutralized aragonite. These results suggested that intracellular calcium release mediates the cellular effects of aragonite. The toxicity of aragonite based on its needle-like structure was also not observed.

Keywords

Aragonite Potassium titanate whisker Inflammation Interleukin-8 Pulmonary toxicity 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

References

  1. Abdelgied M, El-Gazzar AM, Alexander DB, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Abdou KA, Hirose A, Taquahashi Y, Kanno J, Tsuda H, Takahashi S (2018) Potassium octatitanate fibers induce persistent lung and pleural injury and are possibly carcinogenic in male Fischer 344 rats. Cancer Sci 109(7):2164–2177CrossRefGoogle Scholar
  2. Abdelgied M, El-Gazzar AM, Alexander DB, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Abdou KA, Hirose A, Taquahashi Y, Kanno J, Abdelhamid M, Tsuda H, Takahashi S (2019) Pulmonary and pleural toxicity of potassium octatitanate fibers, rutile titanium dioxide nanoparticles, and MWCNT-7 in male Fischer 344 rats. Arch Toxicol 93(4):909–920CrossRefGoogle Scholar
  3. Adachi S, Kawamura K, Takemoto K (2001) A trial on the quantitative risk assessment of man-made mineral fibers by the rat intraperitoneal administration assay using the JFM standard fibrous samples. Ind Health 39(2):168–174CrossRefGoogle Scholar
  4. Chew SH, Toyokuni S (2015) Malignant mesothelioma as an oxidative stress-induced cancer: an update. Free Radic Biol Med 86:166–178CrossRefGoogle Scholar
  5. Donaldson K, Poland CA, Murphy FA, MacFarlane M, Chernova T, Schinwald A (2013) Pulmonary toxicity of carbon nanotubes and asbestos—similarities and differences. Adv Drug Deliv Rev 65(15):2078–2086CrossRefGoogle Scholar
  6. Dong J, Ma Q (2017) Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation. Part Fibre Toxicol 14:18CrossRefGoogle Scholar
  7. Fujita H, Ohashi N, Ogata S (2009) Micronucleus test of asbestos substitutes in chinese hamster lung V79-4 cells. Chemo Bio Integr Manag 5:55–61Google Scholar
  8. Fujita K, Fukuda M, Fukui H, Horie M, Endoh S, Uchida K, Shichiri M, Morimoto Y, Ogami A, Iwahashi H (2015) Intratracheal instillation of single-wall carbon nanotubes in the rat lung induces time-dependent changes in gene expression. Nanotoxicology 9(3):290–301CrossRefGoogle Scholar
  9. Ghio AJ, Soukup JM, Dailey LA, Richards JH, Tong H (2016) The biological effect of asbestos exposure is dependent on changes in iron homeostasis. Inhal Toxicol 28(14):698–705CrossRefGoogle Scholar
  10. Helmig S, Walter D, Putzier J, Maxeiner H, Wenzel S, Schneider J (2018) Oxidative and cytotoxic stress induced by inorganic granular and fibrous particles. Mol Med Rep 17(6):8518–8529Google Scholar
  11. Horie M, Nishio K, Kato H, Endoh S, Fujita K, Nakamura A, Kinugasa S, Hagihara Y, Yoshida Y, Iwahashi H (2014) Evaluation of cellular influences caused by calcium carbonate nanoparticles. Chem Biol Interact 210:64–76CrossRefGoogle Scholar
  12. Ishihara Y, Kyono H, Kohyama N, Otaki N, Serita F, Toya T (2002) Effects of surface characteristics of potassium titanate whisker samples on acute lung injury induced by a single intratracheal administration in rats. Inhal Toxicol 14(5):503–519CrossRefGoogle Scholar
  13. Kane AB, Hurt RH, Gao H (2018) The asbestos-carbon nanotube analogy: an update. Toxicol Appl Pharmacol 361:68–80CrossRefGoogle Scholar
  14. Kasai T, Umeda Y, Ohnishi M, Mine T, Kondo H, Takeuchi T, Matsumoto M, Fukushima S (2016) Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats. Part Fibre Toxicol 13(1):53CrossRefGoogle Scholar
  15. Khaliullin TO, Kisin ER, Murray AR, Yanamala N, Shurin MR, Gutkin DW, Fatkhutdinova LM, Kagan VE, Shvedova AA (2017) Mediation of the single-walled carbon nanotubes induced pulmonary fibrogenic response by osteopontin and TGF-β1. Exp Lung Res 43(8):311–326CrossRefGoogle Scholar
  16. Ljungman AG, Lindahl M, Tagesson C (1994) Asbestos fibres and man made mineral fibres: induction and release of tumour necrosis factor-alpha from rat alveolar macrophages. Occup Environ Med 51(11):777–783CrossRefGoogle Scholar
  17. Ogami A, Morimoto Y, Myojo T, Oyabu T, Murakami M, Nishi K, Kadoya C, Tanaka I (2007) Histopathological changes in rat lung following intratracheal instillation of silicon carbide whiskers and potassium octatitanate whiskers. Inhal Toxicol 19(9):753–758CrossRefGoogle Scholar
  18. Rahman L, Jacobsen NR, Aziz SA, Wu D, Williams A, Yauk CL, White P, Wallin H, Vogel U, Halappanavar S (2017) Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: investigating the mechanisms of pulmonary carcinogenesis. Mutat Res 823:28–44CrossRefGoogle Scholar
  19. Rola-Pleszczynski M, Gouin S, Bégin R (1984) Asbestos-induced lung inflammation. Role of local macrophage-derived chemotactic factors in accumulation of neutrophils in the lungs. Inflammation 8(1):53–62CrossRefGoogle Scholar
  20. Schwarz DS, Blower MD (2016) The endoplasmic reticulum: structure, function and response to cellular signaling. Cell Mol Life Sci 73(1):79–94CrossRefGoogle Scholar
  21. Soeberg MJ, Leigh J, van Zandwijk N (2016) Malignant mesothelioma in Australia 2015: current incidence and asbestos exposure trends. J Toxicol Environ Health B Crit Rev 19(5–6):173–189CrossRefGoogle Scholar
  22. Toyokuni S (2009) Mechanisms of asbestos-induced carcinogenesis. Nagoya J Med Sci 71:1–10Google Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)TakamatsuJapan
  2. 2.Shiraishi Central Laboratories Co., Ltd.AmagasakiJapan

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