Archives of Microbiology

, Volume 201, Issue 1, pp 93–97 | Cite as

Status (on/off) of oipA gene: their associations with gastritis and gastric cancer and geographic origins

  • Mayara Luciana Sallas
  • Mônica Pezenatto dos Santos
  • Wilson Aparecido Orcini
  • Érica Boarato David
  • Rita Luiza Peruquetti
  • Spencer Luiz Marques Payão
  • Lucas Trevizani RasmussenEmail author
Original Paper


Virulence factors of H. pylori, such as outer inflammatory protein A (oipA), are closely involved in the development of gastric diseases such as chronic gastritis and gastric cancer. The functional status of oipA is regulated by a repair mechanism based on CT dinucleotide repeats that influence the reading frame, thus granting the gene a functional or nonfunctional status; in other words, the functional status of the oipA gene seems to be associated with the development of gastric diseases. This study sought to detect the presence of the oipA gene and to determine its functional status in patients with gastric diseases. We analyzed 516 biopsy samples (101 with normal gastric tissue, 365 with chronic gastritis, and 50 with gastric cancer). The presence of oipA was determined by PCR, and the gene status was determined using sequencing reactions. The oipA gene was found to be associated with the development of chronic gastritis, and the “on” status of the gene was the most frequent in patients with gastric cancer who were from Western countries. The CT repeats revealed geographic characteristics, but it is the functional status of the oipA gene that seems to be involved in the development of gastric diseases and in the development of gastric cancer in particular.


Gastric cancer Helicobacter pylorioipVirulence factor 



This study was supported by the State of São Paulo Research Foundation (FAPESP) for the funding of this research (Grant numbers: 2015/11371-5 and 2015/15253-7).


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Mayara Luciana Sallas
    • 1
  • Mônica Pezenatto dos Santos
    • 1
  • Wilson Aparecido Orcini
    • 1
  • Érica Boarato David
    • 1
  • Rita Luiza Peruquetti
    • 1
  • Spencer Luiz Marques Payão
    • 2
  • Lucas Trevizani Rasmussen
    • 1
    • 2
    Email author
  1. 1.Universidade do Sagrado Coração (USC), Pró-Reitoria de Pesquisa e Pós-graduaçãoBauruBrazil
  2. 2.Faculdade de Medicina de Marília (FAMEMA)Laboratório de GenéticaMariliaBrazil

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