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Impaired geometry, volumetric density, and microstructure of cortical and trabecular bone assessed by HR-pQCT in both sporadic and MEN1-related primary hyperparathyroidism

  • W. Wang
  • M. Nie
  • Y. Jiang
  • M. Li
  • X. Meng
  • X. Xing
  • O. WangEmail author
  • W. XiaEmail author
Original Article
  • 44 Downloads

Abstract

Summary

This study evaluated bone features of PHPT using HR-pQCT. The results showed both cortical and trabecular bones were significantly impaired in PHPT patients. Male and female PHPT patients suffered similar damages in bone. HR-pQCT indices were not observed to differ in MEN1 and sporadic PHPT patients.

Introduction

High-resolution peripheral quantitative CT is a novel imaging technique used to separately assess trabecular and cortical bone status of the radius and tibia in vivo. Using HR-pQCT, we aimed to evaluate bone features of primary hyperparathyroidism patients in a Chinese population and reveal similarities and differences in bone features in multiple endocrine neoplasia type 1–related PHPT and sporadic PHPT patients in the Chinese population.

Methods

A case-control study was designed. In 58 PHPT patients and 58 sex- and age-matched healthy controls, the distal radius and tibia were scanned using HR-pQCT. Areal bone mineral density (aBMD) was also determined in PHPT patients using dual-energy X-ray absorptiometry (DXA).

Results

In comparison with controls, PHPT patients were observed to exhibit reduced volumetric BMD at the cortical and trabecular compartments, thinner cortices, and more widely spaced trabeculae. Significant differences were still observed when comparing data of female and male patients with age-matched controls separately. MHPT patients (n = 11) were found to have lower aBMD Z-scores in the lumbar spine, trochanteric region, and total hip compared with sporadic PHPT patients (n = 47), while no differences were observed in HR-pQCT indices between the two groups. In multiple linear regression models, no significant correlations were identified between PTH and HR-pQCT indices. However, height was found to positively correlate with HR-pQCT-derived trabecular indices at both the radius and tibia.

Conclusions

PHPT affects geometry, volumetric density, and microstructure in both the cortical and trabecular bones in both male and female Chinese patients. MHPT patients were observed to have reduced aBMD as determined by DXA in the lumbar spine and hip in comparison with sporadic PHPT patients. However, HR-pQCT indices were not observed to differ.

Keywords

Bone microstructure Bone volumetric density High-resolution peripheral quantitative CT Multiple endocrine neoplasia type 1 Primary hyperparathyroidism 

Notes

Acknowledgments

The authors thank the patients for their participation in the study.

Funding information

This work was financially supported by the Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine (CAMS-I2M) and the National Natural Science Foundation of China (No. 81100559).

Compliance with ethical standards

The present study was approved by the Ethics Committee of Peking Union Medical College Hospital. Written informed content was obtained from all subjects, and this study was carried out according to the principles defined in the Declaration of Helsinki.

Conflicts of interest

None.

Supplementary material

198_2019_5186_MOESM1_ESM.docx (53 kb)
ESM 1 (DOCX 53 kb)

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2019

Authors and Affiliations

  1. 1.Key laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical CollegeChinese Academy of Medical SciencesBeijingPeople’s Republic of China
  2. 2.Key Laboratory of Diabetes Mellitus Prevention and Research, Department of Endocrinology, Beijing Luhe HospitalCapital Medical UniversityBeijingPeople’s Republic of China

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