Association between serum uric acid and bone health in adolescents

  • F. Karimi
  • M. H. Dabbaghmanesh
  • G. R. OmraniEmail author
Original Article



Previous studies are suggestive of the protective role of uric acid on bone in the middle-aged and elderly. Whether this association exists in younger individuals has not been examined. This investigation showed a significant positive association between serum uric acid and bone parameters among Iranian adolescents.


Uric acid (UA) might be linked to bone health, but it is unclear whether its effects on bone are limited to certain population subgroups. This study is aimed at investigating the correlation between serum uric acid levels and bone mineral density (BMD) in Iranian adolescents.


This cross-sectional study was conducted on 413 (221 girls and 192 boys) Iranian adolescents aged 9–19 years. An analysis of anthropometric, biochemical parameters and bone density was performed on the participants. Measurements included serum uric acid, calcium, phosphorus, alkaline phosphatase, albumin, and vitamin D. They were divided according to their serum UA into the low UA group who had UA ≤ 6 mg/dL and the high UA group with UA > 6 mg/dL. BMD and bone mineral content (BMC) were measured in the total body, lumbar spine, and left femoral neck, using dual energy X-ray absorptiometry (DXA), and bone mineral apparent density (BMAD) was calculated.


A Pearson correlation analysis revealed a significant correlation between UA and bone parameters. In multiple regression analyses adjusted for potential confounders, serum UA was proven to be associated with BMD and BMC at all sites. There was no association between UA, serum calcium, and vitamin D concentrations.


Our study, as the first research on adolescents, demonstrated a higher bone density in those who had higher UA levels.


Adolescent Bone mineral apparent density Bone mineral content Bone mineral density Uric acid 



The authors would like to thank all the colleagues working on the project, especially the staff of the Endocrinology and Metabolism Research Center of Shiraz University of Medical Sciences, for their cooperation. The authors also wish to thank Mr. H. Argasi at the Research Consultation Center (RCC) of Shiraz University of Medical Sciences for his assistance in editing this manuscript.


This work was financially supported by the research Vice Chancellor of Shiraz University of Medical Sciences (grant number 9591).

Compliance with ethical standards

Ethical approval

All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflicts of interest



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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2019

Authors and Affiliations

  1. 1.Endocrinology and Metabolism Research CenterShiraz University of Medical SciencesShirazIran

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