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International Urogynecology Journal

, Volume 30, Issue 11, pp 1817–1820 | Cite as

Small fiber polyneuropathy as a potential therapeutic target in interstitial cystitis/bladder pain syndrome

  • Catherine A. Matthews
  • Shaun P. Deveshwar
  • Robert J. Evans
  • Gopal Badlani
  • Stephen J. WalkerEmail author
Review Article

Abstract

Introduction and hypothesis

Interstitial cystitis/bladder pain syndrome (IC/BPS) and fibromyalgia (FM) are frequently co-occurring medical diagnoses in patients referred to the urology clinic for secondary and tertiary treatment options.

Methods

Abundant literature has shown that many patients with FM have small fiber polyneuropathy (SFPN) that can be confirmed via skin punch biopsy and immunological staining to measure nerve density.

Results and conclusions

This finding of SFPN provides a therapeutic target for FM and in this article we hypothesize and provide rationale for the idea that this same phenomenon (SFPN) might explain, in some IC/BPS patients, the finding of widespread pain and likewise provide a therapeutic target for these patients.

Keywords

Polyneuropathy Interstitial cystitis/bladder pain syndrome Fibromyalgia 

Notes

Funding

This study was funded by NIH/NIDDK Grant 5R21DK106554-02 (SJW).

Compliance with ethical standards

Conflicts of interest

None.

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Copyright information

© The International Urogynecological Association 2019

Authors and Affiliations

  1. 1.Department of Urology/Female Pelvic HealthWake Forest Baptist Medical CenterWinston-SalemUSA
  2. 2.Wake Forest Institute for Regenerative MedicineWake Forest Baptist Medical CenterWinston SalemUSA

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