International Urogynecology Journal

, Volume 30, Issue 11, pp 1887–1893 | Cite as

Surgical treatment of primary uterine prolapse: a comparison of vaginal native tissue surgical techniques

  • Karen Ruben HusbyEmail author
  • Michael Due Larsen
  • Gunnar Lose
  • Niels Klarskov
Original Article


Introduction and hypothesis

Uterine prolapse is a common diagnosis. Today no consensus exists on which operation technique is ideal to treat apical prolapse. Vaginal hysterectomy (VH) with suspension of the vaginal cuff is the most frequently used. The popularity of uterus-preserving techniques is increasing. The aim of this study was to compare the efficiency of vaginal native tissue operations to treat primary apical prolapse, evaluated on risk of relapse surgery.


Data were obtained from the Danish National Patient Registry (NPR), which contains all operations performed in Denmark. Patients operated on for primary apical prolapse in Denmark 2010–2016 were included and followed until 2017. Clinical data were obtained from the Danish Urogynecological Database. Patients who were previously hysterectomized or operated on for prolapse in the apical compartment were excluded. Data were analyzed using Cox proportional hazard regression analysis and adjusted for age, BMI, smoking, preoperative prolapse stage and previous POP operations.


In total, 7247 operations were included. The hazard ratio (HR) for relapse operation in the apical compartment was significantly higher after sacrospinous hysteropexy (SH) compared with the Manchester-Fothergill procedure (MP) [40.2 confidence interval (CI) 21.6–74.7] and VH (8.5 CI: 6.0–12.1). Likewise, the HR was higher in the anterior compartment after SH compared with MP (4.3 CI: 2.9–6.4) and VH (2.8 CI: 2.0–4.0). No convincing difference was found in the posterior compartment. The 5-year reoperation rates were 30%, 7% and 11% after SH, MP, and VH, respectively.


Sacrospinous hysteropexy has exceedingly high numbers of reoperations due to prolapse recurrence.


Pelvic organ prolapse (POP) Apical prolapse Manchester-Fothergill procedure Vaginal hysterectomy Sacrospinous hysteropexy 



The American Society of Anesthesiologists


Body mass index


The Danish Urogynecological Database


Manchester-Fothergill procedure


Sacrospinous hysteropexy


Urinary incontinence


Vaginal hysterectomy


Compliance with ethical standards

Conflict of interest

KR Husby, MD Larsen and G Lose have no disclosures. N Klarskov has received funding from Astellas Pharma and Contura outside the study.


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Copyright information

© The International Urogynecological Association 2019

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyHerlev and Gentofte University HospitalHerlevDenmark
  2. 2.University of CopenhagenCopenhagenDenmark
  3. 3.Center for Clinical EpidemiologyOdense University HospitalOdenseDenmark
  4. 4.Research Unit of Clinical EpidemiologyUniversity of Southern DenmarkOdenseDenmark

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