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Evaluation of COLIA1-1997 G/T polymorphism as a related factor to genital prolapse

  • Claudia Cristina Palos
  • Beatriz Ferreira Timm
  • Denise de Souza Paulo
  • Cesar Eduardo Fernandes
  • Ricardo Peres de Souto
  • Emerson Oliveira
Original Article
  • 57 Downloads

Abstract

Introduction and hypothesis

Pelvic organ prolapse has a multifactorial etiology. There is increasing evidence that genetic factors greatly impact its development. This study aimed to evaluate the possible relation of the collagenous polymorphism −1997 G/T with genital prolapse in Brazilian women.

Methods

A cohort study of 180 women with stage 0 or I (group A) pelvic organ prolapse disorder and 112 women with stage III or IV (group B) was conducted. Blood DNA was isolated, and the −1997 G/T polymorphism was identified by amplifying a region of the COLIA1 gene starting prior to the protein’s coding sequence.

Results

No significant difference in the prevalence of genotypes TG and TT was found between groups (p = 0.67); differences were not found even when patients were grouped by the presence of 0 or ≥ 1 polymorphic alleles (p = 0.46). Age and home birth were found to be independent risk factors for prolapse.

Conclusions

Our study could not find any association between the −1997G/T polymorphism and genital prolapse in Brazilian women.

Keywords

Collagen I A1 gene Pelvic organ prolapse Polymorphism rs1107946 −1997G/T 

Notes

Acknowledgments

The authors thank the FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo) for financially supporting this research under contract 2014/01107-6.

Compliance with ethical standards

Conflicts of interest

None.

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Copyright information

© The International Urogynecological Association 2018

Authors and Affiliations

  • Claudia Cristina Palos
    • 1
    • 2
  • Beatriz Ferreira Timm
    • 3
  • Denise de Souza Paulo
    • 1
  • Cesar Eduardo Fernandes
    • 1
  • Ricardo Peres de Souto
    • 3
  • Emerson Oliveira
    • 1
  1. 1.Department of Urogynecology and Vaginal Surgery within the Discipline of Gynecology at the ABC Medical SchoolSanto AndréBrazil
  2. 2.São PauloBrazil
  3. 3.Department of Morphology and Physiology at the ABC Medical SchoolSanto AndréBrazil

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