Evaluation of COLIA1-1997 G/T polymorphism as a related factor to genital prolapse
- 57 Downloads
Introduction and hypothesis
Pelvic organ prolapse has a multifactorial etiology. There is increasing evidence that genetic factors greatly impact its development. This study aimed to evaluate the possible relation of the collagenous polymorphism −1997 G/T with genital prolapse in Brazilian women.
A cohort study of 180 women with stage 0 or I (group A) pelvic organ prolapse disorder and 112 women with stage III or IV (group B) was conducted. Blood DNA was isolated, and the −1997 G/T polymorphism was identified by amplifying a region of the COLIA1 gene starting prior to the protein’s coding sequence.
No significant difference in the prevalence of genotypes TG and TT was found between groups (p = 0.67); differences were not found even when patients were grouped by the presence of 0 or ≥ 1 polymorphic alleles (p = 0.46). Age and home birth were found to be independent risk factors for prolapse.
Our study could not find any association between the −1997G/T polymorphism and genital prolapse in Brazilian women.
KeywordsCollagen I A1 gene Pelvic organ prolapse Polymorphism rs1107946 −1997G/T
The authors thank the FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo) for financially supporting this research under contract 2014/01107-6.
Compliance with ethical standards
Conflicts of interest
- 15.Haylen BT, de Ridder D, Freeman RM, et al. An international urogynecological association (IUGA)/international continence society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn. 2010;29(1):4–20.Google Scholar
- 21.Cartwright R, Kirby AC, Tikkinen KA, et al. Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women. Am J Obstet Gynecol. 2015;212(199):e1–24.Google Scholar
- 22.Leng B, Zhou Q, Zuo M. Association of COL1A1 Sp1-binding site polymorphism with susceptibility to pelvic organ prolapse: a meta-analysis. Int J Clin Exp Med. 2016;9(2):580–7.Google Scholar