Sustained benefit of autologous matrix-induced chondrogenesis for hip cartilage repair in a recreational athletic population
To investigate the clinical outcome of autologous matrix-induced chondrogenesis (AMIC) implementation for mid-sized chondral lesions of the acetabulum in young active patients, and assess their potential to resume an active lifestyle including return to recreational athletic activities.
Sixty-two patients with full-thickness mid-sized acetabular chondral lesions were studied. All patients who underwent an arthroscopic AMIC procedure for reconstruction of chondral defects were assessed pre-operatively and at least 2 years post-operatively using the Hip disability and Osteoarthritis Outcome Score (HOOS), modified Harris Hip Score (mHHS) and Visual Analog Scale (VAS) for pain.
A significant improvement in all three scores at the time of follow-up was found. The mean HOOS improved from 58.8 ± 7.4 pre-operatively to 90.6 ± 7.1 at follow-up (p < 0.001) while the mean mHHS improved from 53.4 ± 6.6 to 82.4 ± 8.2 (p < 0.001). There was a significant decrease from 4.9 ± 1.1 pre-operatively to 1.1 ± 0.8 post-operatively (p < 0.001) in the VAS pain evaluation, indicating that the patients were satisfied with their relief of pain.
The AMIC procedure is an effective single-stage technique for the reconstruction of mid-size chondral defects of acetabulum in amateur athletes. This intervention enhanced the potential for patients to resume recreational athletic activities and the 2-year clinical outcome as evaluated by the HOOS, mHHS and VAS showed significant improvement over the pre-operative evaluations.
KeywordsAMIC Hip chondral defects Sports, arthroscopic surgery Cartilage repair Regeneration
FT conducted the study, carried out all the operations and had the final checking of the manuscript. MM participated in drafting, critically revising and editing the manuscript, while he participated in the operations performed. DG participated in the conception and design of the study and in the interpretation of data, while he participated in the manuscript drafting and in the operations performed. All authors read and approved the final manuscript.
Compliance with ethical standards
Conflict of interest
All authors declare that they have no competing interests.
No funding or other financial support was received in relation to this study.
Prior to starting the study, the research protocol was reviewed and approved by the institutional review board (IRB) of ATOS Clinic, Heidelberg, Germany (approval number 02/14).
All subjects were in agreement with the testing protocol and gave their informed consent for participation in accordance with our Institutional Review Board procedures.
- 3.Bretschneider H, Trattnig S, Landgraeber S et al (2019) Arthroscopic matrix-associated, injectable autologous chondrocyte transplantation of the hip: significant improvement in patient-related outcome and good transplant quality in MRI assessment. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-019-05466-7 CrossRefPubMedGoogle Scholar
- 17.Körsmeier K, Claßen T, Kamminga M, Rekowski J, Jäger M, Landgraeber S (2016) Arthroscopic three-dimensional autologous chondrocyte transplantation using spheroids for the treatment of full-thickness cartilage defects of the hip joint. Knee Surg Sports Traumatol Arthrosc 24(6):2032–2037CrossRefGoogle Scholar