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Treatment of unstable knee osteochondritis dissecans in the young adult: results and limitations of surgical strategies—The advantages of allografts to address an osteochondral challenge

  • Giuseppe Filardo
  • Luca Andriolo
  • Francesc Soler
  • Massimo Berruto
  • Paolo Ferrua
  • Peter Verdonk
  • Frederic Rongieras
  • Dennis C. Crawford
KNEE
  • 28 Downloads

Abstract

Joint surface incongruence resulting from osteochondritis dissecans (OCD) alters the articular physiologic congruence, increasing the contact stress on adjacent joint surfaces and accelerating wear and the cascade of joint degeneration. Accordingly, the restoration of articular surface integrity is of major importance, especially in young adults where, in lesions left untreated or following simple fragment excision, early osteoarthritis can be anticipated. Therefore, the treatment algorithm in unstable knee OCD of the young adult foresees surgical options to restore the articular surface. Several procedures have been proposed, including refixation of the detached fragment bone marrow stimulation, osteochondral autograft implantation, fresh osteochondral allograft transplantation, and cell-based or cell-free regenerative techniques. The aim of this review was to summarize the evidence for these surgical strategies, reporting their results and limitations. The overall evidence documents positive results for each of the assorted surgical procedures applied to treat unstable OCD, thus indicating support for their selected use to treat osteochondral defects paying particular attention to their specific indications for the lesion characteristics. The fixation of a good quality fragment should be pursued as a first option, while unfixable small lesions may benefit from autografts. For large lesions, available cell-based or cell-free osteochondral scaffold are a feasible solution but with limitation in terms of regenerated tissue quality. In this light, fresh allografts may offer articular surface restoration with viable physiologic osteochondral tissue providing a predictably successful outcome, and therefore they may currently represent the most suitable option to treat unstable irreparable OCD lesion in young adults.

Level of evidence

V.

Keywords

Osteochondritis dissecans Young adult Surgical treatment Knee Osteochondral Cartilage Scaffold Allograft 

Notes

Funding

There is no funding source.

Compliance with ethical standards

Conflict of interest

GF is a consultant for Finceramica Faenza Spa, Fidia Farmaceutica, Cartiheal Ltd, EON medica; received institutional support from Finceramica Faenza Spa, Fidia Farmaceutica, IGEA Biomedical, Zimmer Biomet, Kensey Nash. PV is a consultant for DePuy Synthes, Smith and Nephew, Conmed, Active implants. LA, FS, MB, PF, FR and DCC have nothing to disclose.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
  2. 2.
    Aglietti P, Ciardullo A, Giron F, Ponteggia F (2001) Results of arthroscopic excision of the fragment in the treatment of osteochondritis dissecans of the knee. Arthroscopy 17:741–746CrossRefPubMedGoogle Scholar
  3. 3.
    Anderson AF, Pagnani MJ (1997) Osteochondritis dissecans of the femoral condyles. Long-term results of excision of the fragment. Am J Sports Med 25:830–834CrossRefPubMedGoogle Scholar
  4. 4.
    Andriolo L, Candrian C, Papio T, Cavicchioli A, Perdisa F, Filardo G (2018) Osteochondritis dissecans of the knee-conservative treatment strategies: a systematic review. Cartilage.  https://doi.org/10.1177/1947603518758435 CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Andriolo L, Crawford DC, Reale D, Zaffagnini S, Candrian C, Cavicchioli A et al (2018) Osteochondritis Dissecans of the Knee: Etiology and Pathogenetic Mechanisms. A Systematic Review. Cartilage.  https://doi.org/10.1177/1947603518786557 CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Assenmacher AT, Pareek A, Reardon PJ, Macalena JA, Stuart MJ, Krych AJ (2016) Long-term outcomes after osteochondral allograft: a systematic review at long-term follow-up of 12.3 years. Arthroscopy 32:2160–2168CrossRefPubMedGoogle Scholar
  7. 7.
    Barrett I, King AH, Riester S, van Wijnen A, Levy BA, Stuart MJ et al (2016) Internal fixation of unstable osteochondritis dissecans in the skeletally mature knee with metal screws. Cartilage 7:157–162CrossRefPubMedGoogle Scholar
  8. 8.
    Bartlett W, Gooding CR, Carrington RW, Skinner JA, Briggs TW, Bentley G (2005) Autologous chondrocyte implantation at the knee using a bilayer collagen membrane with bone graft. A preliminary report. J Bone Joint Surg Br 87:330–332CrossRefPubMedGoogle Scholar
  9. 9.
    Berruto M, Ferrua P, Uboldi F, Pasqualotto S, Ferrara F, Carimati G et al (2016) Can a biomimetic osteochondral scaffold be a reliable alternative to prosthetic surgery in treating late-stage SPONK? Knee 23:936–941CrossRefPubMedGoogle Scholar
  10. 10.
    Bhattacharjee A, McCarthy HS, Tins B, Roberts S, Kuiper JH, Harrison PE et al (2016) Autologous bone plug supplemented with autologous chondrocyte implantation in osteochondral defects of the knee. Am J Sports Med 44:1249–1259CrossRefPubMedGoogle Scholar
  11. 11.
    Black LO, Ko JK, Quilici SM, Crawford DC (2016) Fresh osteochondral allograft to the humeral head for treatment of an engaging reverse hill-sachs lesion: technical case report and literature review. Orthop J Sports Med 4:2325967116670376CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Bohndorf K (1998) Osteochondritis (osteochondrosis) dissecans: a review and new MRI classification. Eur Radiol 8:103–112CrossRefPubMedGoogle Scholar
  13. 13.
    Bradley J, Dandy DJ (1989) Results of drilling osteochondritis dissecans before skeletal maturity. J Bone Joint Surg Br 71:642–644CrossRefPubMedGoogle Scholar
  14. 14.
    Brittberg M (2012) How to treat patients with osteochondritis dissecans (juvenile and adult). In: Brittberg M, Gobbi A, Imhoff A, Kon E, Madry H (eds) Cartilage repair. Clinical guidelines. DJO Publications, Guildford, pp 171–184Google Scholar
  15. 15.
    Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331:889–895CrossRefPubMedGoogle Scholar
  16. 16.
    Brittberg M, Winalski CS (2003) Evaluation of cartilage injuries and repair. J Bone Joint Surg Am 85 A Suppl 2:58–69CrossRefGoogle Scholar
  17. 17.
    Brix M, Kaipel M, Kellner R, Schreiner M, Apprich S, Boszotta H et al (2016) Successful osteoconduction but limited cartilage tissue quality following osteochondral repair by a cell-free multilayered nano-composite scaffold at the knee. Int Orthop 40:625–632CrossRefPubMedGoogle Scholar
  18. 18.
    Brown D, Shirzad K, Lavigne SA, Crawford DC (2011) Osseous integration after fresh osteochondral allograft transplantation to the distal femur: a prospective evaluation using computed tomography. Cartilage 2:337–345CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Brown DS, Durkan MG, Foss EW, Szumowski J, Crawford DC (2014) Temporal in vivo assessment of fresh osteochondral allograft transplants to the distal aspect of the femur by dGEMRIC (delayed gadolinium-enhanced MRI of cartilage) and zonal T2 mapping MRI. J Bone Joint Surg Am 96:564–572CrossRefPubMedGoogle Scholar
  20. 20.
    Buckwalter JA, Anderson DD, Brown TD, Tochigi Y, Martin JA (2013) The Roles of mechanical stresses in the pathogenesis of osteoarthritis: implications for treatment of joint injuries. Cartilage 4:286–294CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Bugbee WD, Convery FR (1999) Osteochondral allograft transplantation. Clin Sports Med 18:67–75CrossRefPubMedGoogle Scholar
  22. 22.
    Bugbee WD, Pallante-Kichura AL, Gortz S, Amiel D, Sah R (2016) Osteochondral allograft transplantation in cartilage repair: Graft storage paradigm, translational models, and clinical applications. J Orthop Res 34:31–38CrossRefGoogle Scholar
  23. 23.
    Camathias C, Gogus U, Hirschmann MT, Rutz E, Brunner R, Haeni D et al (2015) Implant failure after biodegradable screw fixation in osteochondritis dissecans of the knee in skeletally immature patients. Arthroscopy 31:410–415CrossRefPubMedGoogle Scholar
  24. 24.
    Carey JL, Wall EJ, Grimm NL, Ganley TJ, Edmonds EW, Anderson AF et al (2016) Novel arthroscopic classification of osteochondritis dissecans of the knee: a multicenter reliability study. Am J Sports Med 44:1694–1698CrossRefPubMedGoogle Scholar
  25. 25.
    Chahal J, Gross AE, Gross C, Mall N, Dwyer T, Chahal A et al (2013) Outcomes of osteochondral allograft transplantation in the knee. Arthroscopy 29:575–588CrossRefPubMedGoogle Scholar
  26. 26.
    Christensen BB, Foldager CB, Jensen J, Jensen NC, Lind M (2016) Poor osteochondral repair by a biomimetic collagen scaffold: 1- to 3-year clinical and radiological follow-up. Knee Surg Sports Traumatol Arthrosc 24:2380–2387CrossRefPubMedGoogle Scholar
  27. 27.
    Cole BJ, DeBerardino T, Brewster R, Farr J, Levine DW, Nissen C et al (2012) Outcomes of autologous chondrocyte implantation in study of the treatment of articular repair (STAR) patients with osteochondritis dissecans. Am J Sports Med 40:2015–2022CrossRefPubMedGoogle Scholar
  28. 28.
    Cook JL, Stoker AM, Stannard JP, Kuroki K, Cook CR, Pfeiffer FM et al (2014) A novel system improves preservation of osteochondral allografts. Clin Orthop Relat Res 472:3404–3414CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Cotter EJ, Frank RM, Wang KC, Totlis T, Poland S, Meyer MA et al (2018) Clinical outcomes of osteochondral allograft transplantation for secondary treatment of osteochondritis dissecans of the knee in skeletally mature patients. Arthroscopy 34:1105–1112CrossRefPubMedGoogle Scholar
  30. 30.
    Crawford DC (2017) Personal communication. Metrics of Osteochondral Allograft Study Group Meeting, ChicagoGoogle Scholar
  31. 31.
    Crawford DC, Safran MR (2006) Osteochondritis dissecans of the knee. J Am Acad Orthop Surg 14:90–100CrossRefPubMedGoogle Scholar
  32. 32.
    Cugat R, Garcia M, Cusco X, Monllau JC, Vilaro J, Juan X et al (1993) Osteochondritis dissecans: a historical review and its treatment with cannulated screws. Arthroscopy 9:675–684CrossRefPubMedGoogle Scholar
  33. 33.
    Dean CS, Chahla J, Serra Cruz R, LaPrade RF (2016) Fresh osteochondral allograft transplantation for treatment of articular cartilage defects of the knee. Arthrosc Tech 5:e157–e161CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Delcogliano M, Menghi A, Placella G, Speziali A, Cerulli G, Carimati G et al (2014) Treatment of osteochondritis dissecans of the knee with a biomimetic scaffold. A prospective multicenter study. Joints 2:102–108CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Detterline AJ, Goldstein JL, Rue JP, Bach BR Jr (2008) Evaluation and treatment of osteochondritis dissecans lesions of the knee. J Knee Surg 21:106–115CrossRefPubMedGoogle Scholar
  36. 36.
    Dines JS, Fealy S, Potter HG, Warren RF (2008) Outcomes of osteochondral lesions of the knee repaired with a bioabsorbable device. Arthroscopy 24:62–68CrossRefPubMedGoogle Scholar
  37. 37.
    Drez D Jr (2012) Antegrade versus retrograde. Am J Sports Med 40:NP7; author reply NP7CrossRefPubMedGoogle Scholar
  38. 38.
    Ellermann JM, Donald B, Rohr S, Takahashi T, Tompkins M, Nelson B et al (2016) Magnetic resonance imaging of osteochondritis dissecans: validation study for the ICRS classification system. Acad Radiol 23:724–729CrossRefGoogle Scholar
  39. 39.
    Emmerson BC, Gortz S, Jamali AA, Chung C, Amiel D, Bugbee WD (2007) Fresh osteochondral allografting in the treatment of osteochondritis dissecans of the femoral condyle. Am J Sports Med 35:907–914CrossRefGoogle Scholar
  40. 40.
    Federico DJ, Lynch JK, Jokl P (1990) Osteochondritis dissecans of the knee: a historical review of etiology and treatment. Arthroscopy 6:190–197CrossRefPubMedGoogle Scholar
  41. 41.
    Filardo G, Drobnic M, Perdisa F, Kon E, Hribernik M, Marcacci M (2014) Fibrin glue improves osteochondral scaffold fixation: study on the human cadaveric knee exposed to continuous passive motion. Osteoarthritis Cartilage 22:557–565CrossRefPubMedGoogle Scholar
  42. 42.
    Filardo G, Kon E, Berruto M, Di Martino A, Patella S, Marcheggiani Muccioli GM et al (2012) Arthroscopic second generation autologous chondrocytes implantation associated with bone grafting for the treatment of knee osteochondritis dissecans: Results at 6 years. Knee 19:658–663CrossRefPubMedGoogle Scholar
  43. 43.
    Filardo G, Kon E, Di Martino A, Busacca M, Altadonna G, Marcacci M (2013) Treatment of knee osteochondritis dissecans with a cell-free biomimetic osteochondral scaffold: clinical and imaging evaluation at 2-year follow-up. Am J Sports Med 41:1786–1793CrossRefPubMedGoogle Scholar
  44. 44.
    Filardo G, Kon E, Di Martino A, Perdisa F, Busacca M, Tentoni F et al (2014) Is the clinical outcome after cartilage treatment affected by subchondral bone edema? Knee Surg Sports Traumatol Arthrosc 22:1337–1344CrossRefPubMedGoogle Scholar
  45. 45.
    Fokter SK, Strahovnik A, Kos D, Dovnik A, Fokter N (2012) Long term results of operative treatment of knee osteochondritis dissecans. Wien Klin Wochenschr 124:699–703CrossRefPubMedGoogle Scholar
  46. 46.
    Garrett JC (1994) Fresh osteochondral allografts for treatment of articular defects in osteochondritis dissecans of the lateral femoral condyle in adults. Clin Orthop Relat Res 33–37Google Scholar
  47. 47.
    Gracitelli GC, Meric G, Pulido PA, Gortz S, De Young AJ, Bugbee WD (2015) Fresh osteochondral allograft transplantation for isolated patellar cartilage injury. Am J Sports Med 43:879–884CrossRefPubMedGoogle Scholar
  48. 48.
    Gracitelli GC, Meric G, Pulido PA, McCauley JC, Bugbee WD (2015) Osteochondral allograft transplantation for knee lesions after failure of cartilage repair surgery. Cartilage 6:98–105CrossRefPubMedPubMedCentralGoogle Scholar
  49. 49.
    Grimm NL, Weiss JM, Kessler JI, Aoki SK (2014) Osteochondritis dissecans of the knee: pathoanatomy, epidemiology, and diagnosis. Clin Sports Med 33:181–188CrossRefPubMedGoogle Scholar
  50. 50.
    Gudas R, Simonaityte R, Cekanauskas E, Tamosiunas R (2009) A prospective, randomized clinical study of osteochondral autologous transplantation versus microfracture for the treatment of osteochondritis dissecans in the knee joint in children. J Pediatr Orthop 29:741–748CrossRefPubMedGoogle Scholar
  51. 51.
    Hefti F, Beguiristain J, Krauspe R, Moller-Madsen B, Riccio V, Tschauner C et al (1999) Osteochondritis dissecans: a multicenter study of the European Pediatric Orthopedic Society. J Pediatr Orthop B 8:231–245PubMedPubMedCentralGoogle Scholar
  52. 52.
    Hughston JC, Hergenroeder PT, Courtenay BG (1984) Osteochondritis dissecans of the femoral condyles. J Bone Joint Surg Am 66:1340–1348CrossRefPubMedGoogle Scholar
  53. 53.
    Kane MS, Lau K, Crawford DC (2017) Rehabilitation and postoperative management practices after osteochondral allograft transplants to the distal femur: a report from the metrics of osteochondral allografts (MOCA) study group 2016 survey. Sports Health.  https://doi.org/10.1177/1941738117717011 CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Kivisto R, Pasanen L, Leppilahti J, Jalovaara P (2002) Arthroscopic repair of osteochondritis dissecans of the femoral condyles with metal staple fixation: a report of 28 cases. Knee Surg Sports Traumatol Arthrosc 10:305–309CrossRefPubMedGoogle Scholar
  55. 55.
    Kocher MS, Tucker R, Ganley TJ, Flynn JM (2006) Management of osteochondritis dissecans of the knee: current concepts review. Am J Sports Med 34:1181–1191CrossRefPubMedPubMedCentralGoogle Scholar
  56. 56.
    Koh JL, Kowalski A, Lautenschlager E (2006) The effect of angled osteochondral grafting on contact pressure: a biomechanical study. Am J Sports Med 34:116–119CrossRefPubMedGoogle Scholar
  57. 57.
    Kon E, Delcogliano M, Filardo G, Altadonna G, Marcacci M (2009) Novel nano-composite multi-layered biomaterial for the treatment of multifocal degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc 17:1312–1315CrossRefPubMedPubMedCentralGoogle Scholar
  58. 58.
    Kon E, Filardo G, Di Martino A, Busacca M, Moio A, Perdisa F et al (2014) Clinical results and MRI evolution of a nano-composite multilayered biomaterial for osteochondral regeneration at 5 years. Am J Sports Med 42:158–165CrossRefPubMedGoogle Scholar
  59. 59.
    Kon E, Mutini A, Arcangeli E, Delcogliano M, Filardo G, Nicoli Aldini N et al (2010) Novel nanostructured scaffold for osteochondral regeneration: pilot study in horses. J Tissue Eng Regen Med 4:300–308CrossRefPubMedGoogle Scholar
  60. 60.
    Kon E, Roffi A, Filardo G, Tesei G, Marcacci M (2015) Scaffold-based cartilage treatments: with or without cells? A systematic review of preclinical and clinical evidence. Arthroscopy 31:767–775CrossRefPubMedGoogle Scholar
  61. 61.
    Konig F (2013) The classic: on loose bodies in the joint. 1887. Clin Orthop Relat Res 471:1107–1115CrossRefPubMedPubMedCentralGoogle Scholar
  62. 62.
    Kouzelis A, Plessas S, Papadopoulos AX, Gliatis I, Lambiris E (2006) Herbert screw fixation and reverse guided drillings, for treatment of types III and IV osteochondritis dissecans. Knee Surg Sports Traumatol Arthrosc 14:70–75CrossRefPubMedGoogle Scholar
  63. 63.
    Kramer DE, Glotzbecker MP, Shore BJ, Zurakowski D, Yen YM, Kocher MS et al (2015) Results of surgical management of osteochondritis dissecans of the ankle in the pediatric and adolescent population. J Pediatr Orthop 35:725–733CrossRefPubMedGoogle Scholar
  64. 64.
    LaPrade RF, Bursch LS, Olson EJ, Havlas V, Carlson CS (2008) Histologic and immunohistochemical characteristics of failed articular cartilage resurfacing procedures for osteochondritis of the knee: a case series. Am J Sports Med 36:360–368CrossRefPubMedGoogle Scholar
  65. 65.
    Levy YD, Gortz S, Pulido PA, McCauley JC, Bugbee WD (2013) Do fresh osteochondral allografts successfully treat femoral condyle lesions? Clin Orthop Relat Res 471:231–237CrossRefPubMedGoogle Scholar
  66. 66.
    Linden B (1976) The incidence of osteochondritis dissecans in the condyles of the femur. Acta Orthop Scand 47:664–667CrossRefPubMedGoogle Scholar
  67. 67.
    Linden B (1977) Osteochondritis dissecans of the femoral condyles: a long-term follow-up study. J Bone Joint Surg Am 59:769–776CrossRefPubMedGoogle Scholar
  68. 68.
    Louisia S, Beaufils P, Katabi M, Robert H (2003) Transchondral drilling for osteochondritis dissecans of the medial condyle of the knee. Knee Surg Sports Traumatol Arthrosc 11:33–39CrossRefPubMedGoogle Scholar
  69. 69.
    Lyon R, Nissen C, Liu XC, Curtin B (2013) Can fresh osteochondral allografts restore function in juveniles with osteochondritis dissecans of the knee? Clin Orthop Relat Res 471:1166–1173CrossRefPubMedGoogle Scholar
  70. 70.
    Magnussen RA, Carey JL, Spindler KP (2009) Does operative fixation of an osteochondritis dissecans loose body result in healing and long-term maintenance of knee function? Am J Sports Med 37:754–759CrossRefPubMedPubMedCentralGoogle Scholar
  71. 71.
    Makino A, Muscolo DL, Puigdevall M, Costa-Paz M, Ayerza M (2005) Arthroscopic fixation of osteochondritis dissecans of the knee: clinical, magnetic resonance imaging, and arthroscopic follow-up. Am J Sports Med 33:1499–1504CrossRefPubMedGoogle Scholar
  72. 72.
    Marcacci M, Filardo G, Kon E (2013) Treatment of cartilage lesions: what works and why? Injury 44(Suppl 1):S11–S15CrossRefPubMedGoogle Scholar
  73. 73.
    Maury AC, Safir O, Heras FL, Pritzker KP, Gross AE (2007) Twenty-five-year chondrocyte viability in fresh osteochondral allograft. A case report. J Bone Joint Surg Am 89:159–165CrossRefPubMedGoogle Scholar
  74. 74.
    McAllister DR, Joyce MJ, Mann BJ, Vangsness CT Jr (2007) Allograft update: the current status of tissue regulation, procurement, processing, and sterilization. Am J Sports Med 35:2148–2158CrossRefPubMedGoogle Scholar
  75. 75.
    Merchan EC, Galindo E (1991) Cannulated screw breaking in arthroscopic surgery of osteochondritis dissecans of the knee: a case report. Arthroscopy 7:108–110CrossRefPubMedGoogle Scholar
  76. 76.
    Mesgarzadeh M, Sapega AA, Bonakdarpour A, Revesz G, Moyer RA, Maurer AH et al (1987) Osteochondritis dissecans: analysis of mechanical stability with radiography, scintigraphy, and MR imaging. Radiology 165:775–780CrossRefPubMedGoogle Scholar
  77. 77.
    Meyer MA, McCarthy MA, Gitelis ME, Poland SG, Urita A, Chubinskaya S et al (2017) Effectiveness of lavage techniques in removing immunogenic elements from osteochondral allografts. Cartilage 8:369–373CrossRefPubMedGoogle Scholar
  78. 78.
    Miniaci A, Tytherleigh-Strong G (2007) Fixation of unstable osteochondritis dissecans lesions of the knee using arthroscopic autogenous osteochondral grafting (mosaicplasty). Arthroscopy 23:845–851CrossRefPubMedGoogle Scholar
  79. 79.
    Mirzayan R, Lim MJ (2016) Fresh osteochondral allograft transplantation for osteochondritis dissecans of the capitellum in baseball players. J Shoulder Elbow Surg 25:1839–1847CrossRefPubMedGoogle Scholar
  80. 80.
    Murphy RT, Pennock AT, Bugbee WD (2014) Osteochondral allograft transplantation of the knee in the pediatric and adolescent population. Am J Sports Med 42:635–640CrossRefPubMedGoogle Scholar
  81. 81.
    Nakagawa T, Kurosawa H, Ikeda H, Nozawa M, Kawakami A (2005) Internal fixation for osteochondritis dissecans of the knee. Knee Surg Sports Traumatol Arthrosc 13:317–322CrossRefPubMedGoogle Scholar
  82. 82.
    Niemeyer P, Laute V, John T, Becher C, Diehl P, Kolombe T et al (2016) The effect of cell dose on the early magnetic resonance morphological outcomes of autologous cell implantation for articular cartilage defects in the knee: a randomized clinical trial. Am J Sports Med 44:2005–2014CrossRefPubMedGoogle Scholar
  83. 83.
    Niethammer TR, Pietschmann MF, Horng A, Rossbach BP, Ficklscherer A, Jansson V et al (2014) Graft hypertrophy of matrix-based autologous chondrocyte implantation: a two-year follow-up study of NOVOCART 3D implantation in the knee. Knee Surg Sports Traumatol Arthrosc 22:1329–1336CrossRefPubMedGoogle Scholar
  84. 84.
    Perdisa F, Kon E, Sessa A, Andriolo L, Busacca M, Marcacci M et al (2018) Treatment of knee osteochondritis dissecans with a cell-free biomimetic osteochondral scaffold: clinical and imaging findings at midterm follow-up. Am J Sports Med 46:314–321CrossRefPubMedGoogle Scholar
  85. 85.
    Peterson L, Minas T, Brittberg M, Lindahl A (2003) Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: results at two to ten years. J Bone Joint Surg Am 85 A Suppl 2:17–24CrossRefGoogle Scholar
  86. 86.
    Peterson L, Minas T, Brittberg M, Nilsson A, Sjögren-Jansson E, Lindahl A (2000) 2- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res 212–234Google Scholar
  87. 87.
    Provencher M (2016) Personal communication. Metrics of osteochondral allograft study group meeting, Centenial.Google Scholar
  88. 88.
    Robert H, Elise S, Dubois H (1998) Osteochondritis dissecans of the knee, results of 43 refixations. Arthroskopie 11:177–181CrossRefGoogle Scholar
  89. 89.
    Sadlik B, Gobbi A, Puszkarz M, Klon W, Whyte GP (2017) Biologic inlay osteochondral reconstruction: arthroscopic one-step osteochondral lesion repair in the knee using morselized bone grafting and hyaluronic acid-based scaffold embedded with bone marrow aspirate concentrate. Arthrosc Tech 6:e383–e389CrossRefPubMedPubMedCentralGoogle Scholar
  90. 90.
    Sadr KN, Pulido PA, McCauley JC, Bugbee WD (2016) Osteochondral allograft transplantation in patients with osteochondritis dissecans of the knee. Am J Sports Med 44:2870–2875CrossRefPubMedGoogle Scholar
  91. 91.
    Sales de Gauzy J, Mansat C, Darodes PH, Cahuzac JP (1999) Natural course of osteochondritis dissecans in children. J Pediatr Orthop B 8:26–28PubMedPubMedCentralGoogle Scholar
  92. 92.
    Sanders TL, Pareek A, Obey MR, Johnson NR, Carey JL, Stuart MJ et al (2017) High rate of osteoarthritis after osteochondritis dissecans fragment excision compared with surgical restoration at a mean 16-year follow-up. Am J Sports Med 45:1799–1805CrossRefPubMedGoogle Scholar
  93. 93.
    Sherman SL, Garrity J, Bauer K, Cook J, Stannard J, Bugbee W (2014) Fresh osteochondral allograft transplantation for the knee: current concepts. J Am Acad Orthop Surg 22:121–133PubMedPubMedCentralGoogle Scholar
  94. 94.
    Smolders JM, Kock NB, Koeter S, Van Susante JL (2010) Osteochondral autograft transplantation for osteochondritis dissecans of the knee. Preliminary results of a prospective case series. Acta Orthop Belg 76:208–218PubMedPubMedCentralGoogle Scholar
  95. 95.
    Steadman JR, Rodkey WG, Briggs KK, Rodrigo JJ (1999) [The microfracture technic in the management of complete cartilage defects in the knee joint]. Orthopade 28:26–32PubMedPubMedCentralGoogle Scholar
  96. 96.
    Steinhagen J, Bruns J, Deuretzbacher G, Ruether W, Fuerst M, Niggemeyer O (2010) Treatment of osteochondritis dissecans of the femoral condyle with autologous bone grafts and matrix-supported autologous chondrocytes. Int Orthop 34:819–825CrossRefPubMedGoogle Scholar
  97. 97.
    Tabaddor RR, Banffy MB, Andersen JS, McFeely E, Ogunwole O, Micheli LJ et al (2010) Fixation of juvenile osteochondritis dissecans lesions of the knee using poly 96L/4D-lactide copolymer bioabsorbable implants. J Pediatr Orthop 30:14–20CrossRefPubMedGoogle Scholar
  98. 98.
    Tarabella V, Filardo G, Di Matteo B, Andriolo L, Tomba P, Vigano A et al (2016) From loose body to osteochondritis dissecans: a historical account of disease definition. Joints 4:165–170CrossRefPubMedPubMedCentralGoogle Scholar
  99. 99.
    Thomson NL (1987) Osteochondritis dissecans and osteochondral fragments managed by Herbert compression screw fixation. Clin Orthop Relat Res 71–78Google Scholar
  100. 100.
    Torrie AM, Kesler WW, Elkin J, Gallo RA (2015) Osteochondral allograft. Curr Rev Musculoskelet Med 8:413–422CrossRefPubMedPubMedCentralGoogle Scholar
  101. 101.
    Vannini F, Battaglia M, Buda R, Cavallo M, Giannini S (2012) “One step” treatment of juvenile osteochondritis dissecans in the knee: clinical results and T2 mapping characterization. Orthop Clin North Am 43:237–244, viCrossRefPubMedGoogle Scholar
  102. 102.
    VanTienderen RJ, Dunn JC, Kusnezov N, Orr JD (2017) Osteochondral allograft transfer for treatment of osteochondral lesions of the talus: a systematic review. Arthroscopy 33:217–222CrossRefPubMedGoogle Scholar
  103. 103.
    Vijayan S, Bartlett W, Bentley G, Carrington RW, Skinner JA, Pollock RC et al (2012) Autologous chondrocyte implantation for osteochondral lesions in the knee using a bilayer collagen membrane and bone graft: a 2- to 8-year follow-up study. J Bone Joint Surg Br 94:488–492CrossRefPubMedGoogle Scholar
  104. 104.
    Wang CJ (2002) Treatment of focal articular cartilage lesions of the knee with autogenous osteochondral graftsA 2- to 4-year follow-up study. Arch Orthop Trauma Surg 122:169–172CrossRefPubMedGoogle Scholar
  105. 105.
    Weckstrom M, Parviainen M, Kiuru MJ, Mattila VM, Pihlajamaki HK (2007) Comparison of bioabsorbable pins and nails in the fixation of adult osteochondritis dissecans fragments of the knee: an outcome of 30 knees. Am J Sports Med 35:1467–1476CrossRefPubMedGoogle Scholar
  106. 106.
    Williams III RJ, Ranawat AS, Potter HG, Carter T, Warren RF (2007) Fresh stored allografts for the treatment of osteochondral defects of the knee. J Bone Joint Surg Am 89:718–726Google Scholar
  107. 107.
    Yonetani Y, Matsuo T, Nakamura N, Natsuume T, Tanaka Y, Shiozaki Y et al (2010) Fixation of detached osteochondritis dissecans lesions with bioabsorbable pins: clinical and histologic evaluation. Arthroscopy 26:782–789CrossRefPubMedGoogle Scholar
  108. 108.
    Yoshizumi Y, Sugita T, Kawamata T, Ohnuma M, Maeda S (2002) Cylindrical osteochondral graft for osteochondritis dissecans of the knee: a report of three cases. Am J Sports Med 30:441–445CrossRefPubMedGoogle Scholar
  109. 109.
    Zellner J, Grechenig S, Pfeifer CG, Krutsch W, Koch M, Welsch G et al (2017) Clinical and radiological regeneration of large and deep osteochondral defects of the knee by bone augmentation combined with matrix-guided autologous chondrocyte transplantation. Am J Sports Med 45:3069–3080CrossRefPubMedGoogle Scholar

Copyright information

© European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2018

Authors and Affiliations

  1. 1.ATRC, IRCCS Istituto Ortopedico RizzoliBolognaItaly
  2. 2.Clinica Ortopedica e Traumatologica IIIRCCS Istituto Ortopedico RizzoliBolognaItaly
  3. 3.Traumadvance Orthopaedic GroupTerrassaSpain
  4. 4.Dept. of Knee SurgeryASST Pini-CTOMilanItaly
  5. 5.Department of Orthopaedic Surgery, Department of Orthopaedic SurgeryMonica Hospitals, Monica Research Foundation, University HospitalAntwerpBelgium
  6. 6.Service de chirurgie orthopédique et traumatologiqueHôpital d’instruction des armées Desgenettes, Univ Lyon, Université Claude Bernard Lyon 1LyonFrance
  7. 7.Department of Orthopaedics and RehabilitationOregon Health & Science UniversityPortlandUSA

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