Abstract
We report on a patient with chronic myelogenous leukemia who developed bronchiolitis obliterans organizing pneumonia (BOOP) after allogeneic bone marrow transplantation (BMT). A 19-year-old Japanese male complained of dry cough and dyspnea 7 months after BMT. The chest X-ray and computed tomography revealed patchy infiltrates bilaterally. Lung function test, lung biopsy and bronchoalveolar lavage were consistent with the diagnosis of BOOP. The patient also suffered from suspected graft-versus-host disease (GVHD) of the liver, after discontinuation of cyclosporine. Furthermore, prednisolone proved effective against the BOOP and the liver dysfunction. These findings indicate that BOOP is a possible pulmonary manifestation of chronic GVHD, and that immunological mechanisms may have effected the onset of BOOP after BMT in this case.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 18 May 2000 Revised: 30 October 2000 Accepted: 23 May 2001
About this article
Cite this article
Kanamori, H., Mishima, A., Tanaka, M. et al. Bronchiolitis obliterans organizing pneumonia (BOOP) with suspected liver graft-versus-host disease after allogeneic bone marrow transplantation. Transpl Int 14, 266–269 (2001). https://doi.org/10.1007/s001470100330
Published:
Issue Date:
DOI: https://doi.org/10.1007/s001470100330