Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Noninvasive assessment of cardiac risk in type I diabetic patients being evaluated for combined pancreas-kidney transplantation using dipyridamole-MIBI perfusion tomographic scintigraphy

Abstract

This study was performed to determine the value of dipyridamole-99 mTc-methoxy-isobutyl isonitrile perfusion (99 mTC-MIBI) tomographic scintigraphy in the assessment of cardiac risk in patients being evaluated prior to combined pancreas-kidney transplantation (PKT). We performed perfusion tomographic scintigraphy using single photon emission computed tomography (SPECT) on 77 patients. The tomographic images did not show clinically relevant findings in 65 patients. In the remaining 12 patients, coronary arteriography was performed: 2 showed normal results, 4 showed no stenosis, and 6 showed significant stenosis ( ≥ 70 %). Seventy-two patients underwent PKT. During the follow-up (6–48 months), there were seven cardiac events, 4 patients with significant stenosis, and 3 with nonsignificant stenosis upon coronary arteriography, and all had pathological tomographic images. 99 mTc-MIBI tomographic scintigraphy may be useful in identifying patients at low risk of incurring cardiac events after PKT and may, in a large group of patients, obviate the need for routine coronary angiography.

This is a preview of subscription content, log in to check access.

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Author information

Additional information

Received: 6 July 1999/Revised: 11 January 2000/Accepted: 30 May 2000

About this article

Cite this article

Fuster, D., Magriña, J., Ricart, M. et al. Noninvasive assessment of cardiac risk in type I diabetic patients being evaluated for combined pancreas-kidney transplantation using dipyridamole-MIBI perfusion tomographic scintigraphy. Transpl Int 13, 327–332 (2000). https://doi.org/10.1007/s001470050709

Download citation

  • Key words99 mTc-MIBI scintigraphy
  • Dipyridamole
  • Pancreas-kidney transplantation
  • Cardiac risk assessment
  • Diabetes mellitus