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Malakoplakia of the caecum in a kidney-transplant recipient: presentation as acute tumoral perforation and fatal outcome

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Abstract

Malakoplakia is a rare pseudotumoral inflammatory disease known to affect immunocompromised subjects, mainly with a history of recurrent Escherichia coli infection. The urinary tract is the most frequent site of the disease, although all organs can be involved. In the present article, we report a case of malakoplakia of the caecum, that developed in a 52-year-old man, who had received a kidney transplant 9 years before and had a history of recurrent E. coli urinary tract infections. Malakoplakia presented as acute intestinal perforation, and, despite aggressive surgical and medical management, disease progressed toward a fatal outcome due to sepsis and multiple organ failure 9 months later. A defect in the macrophagic activity was demonstrated.

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Received: 21 April 1998 Received after revision: 30 December 1998 Accepted: 4 May 1999

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Berney, T., Chautems, R., Ciccarelli, O. et al. Malakoplakia of the caecum in a kidney-transplant recipient: presentation as acute tumoral perforation and fatal outcome. Transpl Int 12, 293–296 (1999). https://doi.org/10.1007/s001470050227

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  • Key words Malakoplakia
  • Kidney transplantation
  • Immunosuppression
  • Escherichia coli infection
  • Macrophage dysfunction