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Does indocyanine green accurately measure plasma volume independently of its disappearance rate from plasma in critically ill patients?

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Abstract

Objective: To determine whether plasma volume determined by the indocyanine green (ICG) dilution method (PV-ICG) is equally accurate independently of its disappearance rate from plasma in the critically ill.¶Design: Retrospective clinical investigation.¶Setting: Intensive care unit of a university teaching hospital.¶Patients and methods: 192 adult patients were initially enrolled. The PV-ICG and the initial distribution volume of glucose (IDVG) were calculated utilizing a one-compartment model by simultaneous administration of ICG 25 mg and glucose 5 g on the first day of measurement in each patient. Twenty-one patients were excluded from the study because of a higher PV-ICG/IDVG ratio ( > 0.45) indicating apparent overestimation of the PV-ICG associated with the generalized protein capillary leakage. The remaining 171 patients were divided into four groups according to the magnitude of their disappearance rate of ICG from plasma (Ke-ICG).¶Results: Convergence was assumed consistently in each ICG or glucose decay curve, even in the lower Ke-ICG less than 0.10/min. The relationship between the two volumes was not statistically different among groups.¶Conclusions: The results suggest that the measurement of the PV-ICG can be equally accurate independently of its disappearance rate from plasma unless there is generalized protein capillary leakage.

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Received: 10 February 1999/Final revision received: 28 June 1999/Accepted: 21 July 1999

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Ishihara, H., Iwakawa, T., Hasegawa, T. et al. Does indocyanine green accurately measure plasma volume independently of its disappearance rate from plasma in critically ill patients?. Intensive Care Med 25, 1252–1258 (1999). https://doi.org/10.1007/s001340051053

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  • Key words Measurement technique
  • Plasma volume
  • Indocyanine green
  • Glucose
  • Hepatic function