A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC)
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Management algorithms for adult severe traumatic brain injury (sTBI) were omitted in later editions of the Brain Trauma Foundation’s sTBI Management Guidelines, as they were not evidence-based.
We used a Delphi-method-based consensus approach to address management of sTBI patients undergoing intracranial pressure (ICP) monitoring. Forty-two experienced, clinically active sTBI specialists from six continents comprised the panel. Eight surveys iterated queries and comments. An in-person meeting included whole- and small-group discussions and blinded voting. Consensus required 80% agreement. We developed heatmaps based on a traffic-light model where panelists’ decision tendencies were the focus of recommendations.
We provide comprehensive algorithms for ICP-monitor-based adult sTBI management. Consensus established 18 interventions as fundamental and ten treatments not to be used. We provide a three-tier algorithm for treating elevated ICP. Treatments within a tier are considered empirically equivalent. Higher tiers involve higher risk therapies. Tiers 1, 2, and 3 include 10, 4, and 3 interventions, respectively. We include inter-tier considerations, and recommendations for critical neuroworsening to assist the recognition and treatment of declining patients. Novel elements include guidance for autoregulation-based ICP treatment based on MAP Challenge results, and two heatmaps to guide (1) ICP-monitor removal and (2) consideration of sedation holidays for neurological examination.
Our modern and comprehensive sTBI-management protocol is designed to assist clinicians managing sTBI patients monitored with ICP-monitors alone. Consensus-based (class III evidence), it provides management recommendations based on combined expert opinion. It reflects neither a standard-of-care nor a substitute for thoughtful individualized management.
KeywordsBrain injury Head trauma Algorithm Protocol Consensus Intracranial pressure Tiers Seattle SIBICC
Brain Trauma Foundation
Central nervous system
Cerebral perfusion pressure
Diffuse injury as defined in the Marshall CT Head Score
Evacuated mass lesion as defined in the Marshall CT Head Score
External ventricular drain
Glasgow Coma Scale
Head of bed
Imaging and clinical examination
Intensive care unit
Mean arterial pressure
Arterial partial pressure of carbon dioxide
Partial pressure of brain tissue oxygen
Arterial oxygen saturation
The Brain Trauma Foundation (BTF) Guidelines for the Management of Severe Traumatic Brain Injury (sTBI)  have been widely incorporated into practice and associated with a reduction in mortality from sTBI . The first two editions [1, 3] included popular treatment algorithms. However, because different sTBI treatments have been studied in isolation, almost no evidence exists regarding their relative efficacy, sequential ordering or combination as would be required to create evidence-based treatment protocols . Later editions thus recognized that these algorithms could not be based on published evidence and omitted them [5, 6], to the expressed disappointment of many readers. In response to algorithm requests and the paucity of high-quality evidence for sTBI management algorithms, we here use a consensus approach to develop a management algorithm for sTBI that will be useful across a variety of management environments, with the condition that the sTBI patient is admitted to an ICU with an intracranial pressure monitor in situ.
We present a series of consensus-based algorithms for adult sTBI management. Our consensus working group (CWG) established 18 interventions as fundamental to sTBI care and ten treatments not to be used. It also established a three-tier algorithm focused on treating elevated ICP wherein higher tiers involve therapies with higher risk. We suggest considerations to address when advancing from lower to higher tiers and recommendations for critical neuroworsening aimed at assisting the recognition, workup, and treatment of declining patients. Novel elements include guidance for autoregulation-based ICP treatment and the performance of MAP Challenges, as well as two sets of heatmaps to guide (1) consideration of sedation holidays to facilitate neurological examination and (2) ICP-monitor removal.
Forty-two physicians comprised the CWG for the Seattle Severe Traumatic Brain Injury Consensus Conference (SIBICC) algorithm. The panel included ten neurointensivists, 23 neurosurgeons, five neurologist/neurointensivists, two trauma surgeons, and two emergency medicine specialists. We based panel selection on (a) > 10 years clinical experience in sTBI; (b) current, active involvement in acute care management of sTBI patients; (c) representation of involved disciplines; (d) geographic diversity; and (e) ability to commit time to the algorithm development process. We calculated panel size based on logistic considerations. Panelists completed conflict of interest forms relevant to sTBI management. There were no conflicts mandating recusal of any participant. In advance of the meeting all participants were provided with electronic copies of all manuscripts taken as evidence for the 4th edition Brain Trauma Foundation Guidelines for the Management of Severe TBI organized by chapter.
The expressed focus of the effort was to design a management algorithm that would be acceptable to the panel and amenable to application in both neurological and general ICUs by physicians not specialized in neurointensive care. Prior to the meeting, the CWG completed eight web-based surveys (SurveyMonkey Inc., San Mateo, California, USA, www.surveymonkey.com) to determine the algorithm design and focus, explore definitions and thresholds, operationally define treatment modalities, evaluate acceptability and tier assignments of treatment modalities, etc. We combined voting results with panelists’ comments to iterate these surveys to maximize consensus and define areas requiring focus at the in-person meeting.
Two special surveys addressed the timing of ICP monitor removal and the use of sedation holidays for examinations. Early voting using discrete-elements did not progress toward resolution of these multivariate issues, so they were assembled into matrices, each cell of which represented a concatenation of multiple individual clinical indicators. By combining individual panelist’s responses and color-coding the results using a traffic-light model (red-yellow-green), we constructed heatmaps to guide decision-making. We modified the Marshall CT classification  of post-operative imaging for this exercise. The post-surgical CT scans of patients having an evacuated mass lesion (EML) were additionally classified as if they had not had surgery (i.e., DI I–IV) and this ranking was appended to the EML label (e.g., EML/DI IV) in the heatmaps. We did this to increase the sensitivity of post-operative images to indicators of intracranial hypertension for this exercise.
The in-person SIBICC meeting occurred from the 5th to 7th of April 2019 in Seattle, Washington, USA. We used anonymous electronic voting and vote analysis (Electronic Media Services Inc., Gig Harbor Washington, USA, www.electronicmeetingservices.com). Professional, independent non-physician moderators facilitated group discussions. We used small group sessions to address complex issues, with the whole CWG modifying and voting on small-group recommendations. All recommendations were incorporated verbatim into the final product. Unless specifically modified by the CWG, we limited the voting cycle to three iterations, interspersed with discussions. An element formed part of the final recommendations only if it achieved 80% agreement as “acceptable” (voting threshold) by at least 80% of the panelists (a quorum) in the confidential electronic voting. Unresolved issues are reported as such (Supplemental Material).
Donations solicited from industry and other interested parties funded this meeting. In return, they were allowed to silently observe the conference, without any interaction with the panelists or the process. No donors or other outside parties influenced any portion of these recommendations.
Treatment not recommended for use in the management of severe traumatic brain injury (when only ICP is monitored)
Mannitol by non-bolus continuous intravenous infusion
Scheduled infusion of hyperosmolar therapy (e.g., every 4–6 h)
Lumbar CSF drainage
Routine use of steroids
Routine use of therapeutic hypothermia to temperatures below 35 °C due to systemic complications
High-dose propofol to attempt burst suppression
Routinely decreasing PaCO2 below 30 mmHg/4.0 kPa
Routinely raising CPP above 90 mmHg
Sufficient research-based literature on individual ICP treatments exists to allow creation of an evidence report . Unfortunately, there is insufficient research on the amalgamation of these individual treatments into a management algorithm to allow evidence-based development of a treatment approach. Since daily care consists of amalgamating individual treatments into a care plan, leaving this process to individual, non-expert practitioners without specific guidance is undesirable. Despite its limitations and weaknesses, the Delphi method remains the best current methodology for developing recommendations from expert consensus. As an evidentiary basis for prioritizing, sequencing, and combining sTBI treatments does not currently exist, we applied the Delphi method rigorously to this work, concomitantly recognizing the relative weakness of this approach.
Protracted specialist experience provides the expert practitioner repeated feedback on their manner of combining individual therapies. Although neither conditions nor outcomes are rigorously controlled, the impact of many repeated exposures to the influence of their therapeutic approach on short-term results (such as acute ICP control) should bestow a form of wisdom (“Medicine-Based Evidence”; the time-tested experience of an individual practitioner). An individual’s wisdom is likely confounded by factors such as personal biases, technical idiosyncrasies, the care environment, patient population and injury demographics, etc. The concept of a consensus conference is to combine a large cohort of such experts and determine where their experiences overlap. As it is unlikely that individual-specific confounding factors will be shared, areas where there is general agreement should reflect a degree of clinical efficacy. The inclusion of multiple specialties, international sites, and varying practices should improve generalizability. We used this theoretical framework here to construct this set of recommendations.
Even with a large panel, blinded voting, and much discussion, such a process lacks rigor. As well, the observations on which the clinical wisdom is based primarily involve only ICP control and short-term clinical outcome. Therefore, the reader should consider these recommendations as a suggested treatment method without proven superiority over other applicable methods. Although primarily targeted at those with limited experience in monitor-based sTBI management, all practitioners involved in critical care treatment of sTBI patients may find these recommendations useful. They represent a safe and modern approach to sTBI care. They are not a standard of care or even the best treatment approach in a given instance. They are not legally binding. They are not designed as quality assurance monitoring tools. They do not represent the approach of any individual CWG member and should never be substituted for thoughtful clinical judgment. Hopefully, future scientific testing can increase the rigor of these recommendations and quantify their efficacy as steps toward establishing evidence-based algorithm development.
Derived by a large, international, multi-specialty consensus group through a rigorous Delphi-based consensus process, these recommendations are designed to augment other current management-related offerings such as the American College of Surgeons-Trauma Quality Improvement Program (ACS-TQIP) document , into which these recommendations are currently being integrated by the ACS Committee on Trauma (ACS-COT).
Use of these recommendations in clinical practice
Conditions of tiered treatment
The use of tiers attempts to balance the benefits and efficacy of an agent against risks inherent to its use (Fig. 2). General clinical management is considered Tier Zero. Treatment of intracranial hypertension will generally begin at Tier-one. Movement to higher tiers reflects increasingly aggressive interventions. Treatments in any given tier are considered equivalent, with selection of one treatment over another based on individual patient characteristics and physician discretion. During any given episode being addressed, multiple items from a single tier can be trialed individually or in combination with the goal of a rapid response. The provider should maintain awareness of the duration of any episode and consider moving to more aggressive interventions in a higher tier quickly if the patient is not responding. In some cases, it might be preferrable to skip one or more tiers (e.g., choosing to decompress a patient with midline shift due to hemispheric swelling and very high initial ICP). No individual agent or combination thereof is critical to success in managing TBI. Clinical judgment must always determine the final management strategy.
Tier-zero (Fig. 1) recommendations apply to sTBI patients with an ICP monitor in situ who are admitted to an ICU. Management recommendations for sTBI patients without ICP monitoring are published elsewhere . The goal of Tier-zero is to establish a stable, neuroprotective physiologic baseline regardless of eventual ICP readings. Tier-zero sedatives and analgesics target comfort and ventilator tolerance rather than ICP. Temperature management targets avoiding fever (defined by our CWG as core temperature > 38 °C). Consistent with the BTF Guidelines , the minimal cerebral perfusion pressure (CPP) threshold is 60 mmHg.
Tier-one through tier-three (treatment of established intracranial hypertension)
Tier-one (Fig. 2) represents the first foray into managing intracranial hypertension. The CWG adopted the BTF Guidelines’ recommendations for initial ICP and cerebral perfusion pressure (CPP) thresholds (22 mmHg and 60 mmHg, respectively) . Tier-one sedative or analgesic manipulation focuses on lowering ICP. The CWG decided not to recommend one hypertonic solution over the other, or to recognize different dosing levels (e.g., low and high dose) for either. After some discussion, they recommended using the same upper limits for serum sodium and osmolality for both agents.
When ICP is monitored using ventriculostomy, the CWG recommended CSF drainage as a Tier-one treatment. If an intraparenchymal device is used, consider ventriculostomy to enable CSF drainage. As subclinical seizure activity can cause intracranial hypertension, consider EEG monitoring and reconsider 1 week of prophylactic anti-epileptic drugs if not routinely used.
The hazards of routine neuromuscular blockade  prompted discussion regarding its position in Tier-two versus three. The decision to place it at Tier-two includes a recommendation for basing continued administration on efficacy demonstrated during a trial period and to discontinue it as soon as possible.
Known risks of hyperventilation in sTBI  and frequent use of PbtO2 monitoring at many panelists’ centres prompted caution in recommending even mild hyperventilation when brain oxygenation monitoring is not employed. To allow the maximum number of acceptable tools to those employing only ICP monitoring; however, the CWG recommended mild hyperventilation (PaCO2 32–35 mmHg/4.3–4.7 kPa) as a Tier-two treatment. They did not support lower PaCO2 levels and recommended against routine hyperventilation to below 30 mmHg/4.0 kPa.
As increasing CPP can lower ICP if static pressure autoregulation (sPAR) is intact [11, 12, 13], the CWG recommended a simplified method of testing sPAR status based on that of Rosenthal et al. . When CPP is above the lower breakpoint of sPAR and is then raised, the vasoconstriction attendant to active autoregulation decreases cerebral blood volume. This can be observed if the responses are trended, or by comparing the relevant parameters (i.e., ICP, MAP, and CPP) at the beginning and end of the test. As MAP elevation with disrupted sPAR may worsen intracranial hypertension, a practitioner capable of interpreting the results and halting the study should perform the test. If the trial is positive, judgment is required as to whether the benefit of the ICP decrease justifies the risks inherent to pharmacologically raising MAP. Cautious interpretation and application of the results of the MAP Challenge are recommended, as the test results may not be simple to interpret and the status of cerebral pressure autoregulation may not be stable.
Record baseline monitor parameters at the beginning of the challenge (e.g., ICP, MAP and CPP).
Initiate or titrate a vasopressor to increase the MAP by 10 mmHg for up to 20 min.
Observe the interaction between the MAP, ICP, and CPP during the challenge.
Record monitor parameters at the end of the challenge.
Evaluate the observed responses and recorded values for evidence of sPAR status. Disrupted sPAR will present as a sustained increase in ICP with MAP elevation.
Adjust the target MAP back to baseline (disrupted sPAR) or to the chosen new, elevated target (intact sPAR).
Tier-three treatments have the greatest associated risks. The initiation of high-dose barbiturate therapy should be based on the response to a test dose. The CWG recommended EEG monitoring if barbiturates are continued and not titrating the dose upwards if burst suppression occurs, as further reduction in ICP is not anticipated and toxicity increases with dose. The endpoint of barbiturate treatment is ICP control not serum levels or EEG response. Hypotension must be avoided. The CWG supported use of mild hypothermia (35–36 °C) but not routine therapeutic hypothermia to below 35 °C due to systemic complications. The CWG recommended decompressive craniectomy with recognition of the indications and hazards demonstrated by recent RCTs [6, 15, 16].
The CWG recommended against the use of ten management items for treating established intracranial hypertension (Table 1; ≥ 80% consensus). Some are specific pharmacologic agents or means of administering them. There are also specific physiologic parameters viewed as unsafe to exceed during treatment. The panel agreed that there may be circumstances where listed items might be reasonably used by an experienced and expert clinician in infrequent and carefully considered situations.
The CWG did not support hypothermia below 35 °C. Although hypothermia can lower ICP, there are no definitive outcome-based studies supporting recommendations. The evidence against its neuroprotective efficacy and demonstrated associated morbidity  were cited as reasons not to include it until studies on hypothermia-mediated treatment of intracranial hypertension and recovery become available.
Stepping to a higher tier is a potential indicator of increased disease severity. As higher tiers represent interventions with increased associated risks, the CWG recommends reassessing the patient’s basic intra- and extra-cranial physiologic status and reconsidering the surgical status of intracranial mass lesions (e.g., contusions) not previously considered operative. If the patient is at a non-specialist centre at the point of upward tier advancement, the CWG recommended considering consultation with and potential transfer to a TBI center with increased resources if possible within the regional healthcare environment. When desired, transfer is best completed before clinical decline precludes it.
Critical neuroworsening represents a specific situation of critical deterioration requiring emergent evaluation and management. Neuroworsening was first defined retrospectively as a potential intermediate-outcome variable for TBI trials , it was adapted as a clinical variable for the BEST:TRIP trial  and subsequent management studies for limited resource environments . The CWG adapted it here, terming the clinical definition “Critical Neuroworsening”, to promote its recognition as a critical event and guide expeditious evaluation and consideration of empiric therapy.
Weaning ICP treatment
Sedation holiday heatmaps
The CWG recognized the balance between obtaining the most accurate (non-sedated) neurological examination of sTBI patients and the hazards of temporarily halting sedation to perform these examinations. Survey attempts at gaining consensus on relative and absolute contraindications were unsuccessful. The CWG therefore chose to construct matrices representing the most relevant decision variables under differing intracranial hypertension scenarios to recognize the distribution of the panel’s opinions. The resulting heatmaps reflect the variability among expert clinicians in the perceived safety of sedation holidays in monitored sTBI patients. Using these decision-support matrices involves first determining which cell represents the patient in question. In situations where there are no other contraindications, green or “greenish” status supports sedation holiday use in line with the CWG’s procedural recommendations. Red or “reddish” status represents relative recommendation against sedation holiday performance. The large areas appearing “yellowish” represent areas where the recommendations regarding proceeding are qualified, leaving to the clinician to decide if the current risk:benefit ratio might justify a sedation holiday. An alternative approach under “yellowish” conditions is to determine those factors that might be altered to shift the patient to a more highly recommended status. In all cases, however, the final decision is entirely up to the managing physician, with the heatmap serving only as an ancillary “consultation” from the CWG.
Procedural recommendations focus on minimizing risks and enhancing the utility of sedation holidays. Coordinating timing and optimizing the opportunity for all involved parties to be present (e.g., Intensivist, Neurosurgeons, etc.) maximizes the safety and interpretation of sedation holidays under all conditions. Finally, finding a favorable exam during the sedation holiday offers an opportunity to initiate sedation tapering.
ICP monitor removal heatmap
There is little literature regarding how long ICP should be acceptable before monitoring is discontinued. Marked variability in CWG survey results and lack of progression toward resolution over repeated surveys mimicked the sedation holiday conditions. Following the same logic, the CWG created heatmaps for ICP monitor removal. Using them for decision support again involves choosing the relevant heatmap and then the appropriate cell. The implications of the associated color parallel those described for the sedation holiday. Inspection of the heatmap trends confirms the marked variation among panelists. They suggest that 72 h of acceptable ICP is almost universally accepted whereas removal at 24 h is recommended only for patients with fairly benign CTs and favorable exams. The therapeutic intensity required prior to acceptable ICP and the Glasgow Coma Scale  motor score also appear to be strong influences on this decision. There is marked variability in the relative comfort with following the clinical examination versus continued monitoring in sTBI patients without continued intracranial hypertension. The value of the heatmap represents moderation rather than resolution of this controversy.
The goal of these SIBICC recommendations is to fill the void between the currently published evidence-based guidelines and clinical practice, using modern medicine-based-evidence to guide algorithm construction. Such algorithms provided a bridge between evidence-based analyses of individual treatments and the integration of these modalities into the management approach that is necessary at the bedside. The 42 clinically active global thought leaders with long-term experience in acute sTBI management who comprise the CWG used a Delphi-based consensus approach to produce a form of Medicine-Based-Evidence to facilitate the common situation of sTBI management at non-TBI centers. As consensus-based recommendations, they constitute the lowest level of evidence (Class III in the BTF Guidelines methodology ). Recognizing that these are recommendations—a form of multi-physician curbside consult—they are aimed at clinicians not specifically expert in the management of sTBI or those considering initiating ICP monitoring. They may be clinically adopted, adapted, referenced, or otherwise considered by individual physicians or medical centres. They may serve as useful tools for research design and should be subjected to analysis using comparative effectiveness research tools as well as trials. They are offered as guidance only, as a first attempt at filling a gap in the current clinical literature.
We thank our moderators Kevin Dunne and Theodore Michalke, Jone Howard for our audience response system, Kelley Chaddock for extensive administrative support, Peter Hendrickson, PhD for managing our web-based surveys, PJH is supported by the NIHR (Research Professorship, Cambridge BRC and Global Health Research Group on Neurotrauma), and DKM is an Emeritus Senior Investigator of the National Institute of Health Research (UK). We thank our financial supporters who include Adler/Geirsch Attorney at Law, the American Association of Neurological Surgeons/Congress of Neurological Surgeons Section on Neurotrauma and Critical Care, Bard, the Brain Trauma Foundation, DePuy, Hemedex, Integra, the Neurointensive Care Section of the European Society of Intensive Care Medicine, Neurosurgical Society of Australasia, Medtronic, Moberg Research, Natus, Neuroptics, Raumedic, Sophysa, Stryker, and Zoll.
Compliance with ethical standards
Conflicts of interest
No conflicts of interest relevant to this project were identified amongst the authorship group.
- 5.Brain Trauma F, American Association of Neurological S, Congress of Neurological S, Joint Section on N, Critical Care AC, Carney NA, Ghajar J (2007) Guidelines for the management of severe traumatic brain injury. Introduction. J Neurotrauma 24(Suppl 1):S1–S2Google Scholar
- 6.Carney N, Totten AM, O’Reilly C, Ullman JS, Hawryluk GW, Bell MJ, Bratton SL, Chesnut R, Harris OA, Kissoon N, Rubiano AM, Shutter L, Tasker RC, Vavilala MS, Wilberger J, Wright DW, Ghajar J (2017) Guidelines for the management of severe traumatic brain injury. Neurosurgery 80:6–15PubMedPubMedCentralGoogle Scholar
- 8.Trauma ACoSCo (2015) Best practices in the management of traumatic brain injury. In: Book best practices in the management of traumatic brain injuryGoogle Scholar
- 9.Hendrickson P, Pridgeon J, Temkin NR, Videtta W, Petroni G, Lujan S, Guadagnoli N, Urbina Z, Pahnke PB, Godoy D, Pinero G, Lora FS, Aguilera S, Rubiano AM, Morejon CS, Jibaja M, Lopez H, Romero R, Dikmen S, Chaddock K, Chesnut RM (2018) Development of a severe traumatic brain injury consensus-based treatment protocol conference in Latin America. World Neurosurg 110:e952–e957CrossRefGoogle Scholar
- 14.Rosenthal G, Sanchez-Mejia RO, Phan N, Hemphill JC 3rd, Martin C, Manley GT (2011) Incorporating a parenchymal thermal diffusion cerebral blood flow probe in bedside assessment of cerebral autoregulation and vasoreactivity in patients with severe traumatic brain injury. J Neurosurg 114:62–70CrossRefGoogle Scholar
- 15.Cooper DJ, Rosenfeld JV, Murray L, Arabi YM, Davies AR, D’Urso P, Kossmann T, Ponsford J, Seppelt I, Reilly P, Wolfe R, Investigators DT, Australian, New Zealand Intensive Care Society Clinical Trials G (2011) Decompressive craniectomy in diffuse traumatic brain injury. N Engl J Med 364:1493–1502CrossRefGoogle Scholar
- 16.Hutchinson PJ, Kolias AG, Timofeev IS, Corteen EA, Czosnyka M, Timothy J, Anderson I, Bulters DO, Belli A, Eynon CA, Wadley J, Mendelow AD, Mitchell PM, Wilson MH, Critchley G, Sahuquillo J, Unterberg A, Servadei F, Teasdale GM, Pickard JD, Menon DK, Murray GD, Kirkpatrick PJ, Collaborators RET (2016) Trial of decompressive craniectomy for traumatic intracranial hypertension. N Engl J Med 375:1119–1130CrossRefGoogle Scholar
- 17.Cooper DJ, Nichol AD, Bailey M, Bernard S, Cameron PA, Pili-Floury S, Forbes A, Gantner D, Higgins AM, Huet O, Kasza J, Murray L, Newby L, Presneill JJ, Rashford S, Rosenfeld JV, Stephenson M, Vallance S, Varma D, Webb SAR, Trapani T, McArthur C, Investigators PT, the ACTG (2018) Effect of early sustained prophylactic hypothermia on neurologic outcomes among patients with severe traumatic brain injury: the POLAR randomized clinical trial. JAMA 320:2211–2220CrossRefGoogle Scholar
- 18.Morris GF, Juul N, Marshall SB, Benedict B, Marshall LF (1998) Neurological deterioration as a potential alternative endpoint in human clinical trials of experimental pharmacological agents for treatment of severe traumatic brain injuries. Executive Committee of the International Selfotel Trial. Neurosurgery 43:1369–1372 (discussion 1372–1364) PubMedGoogle Scholar
- 19.Chesnut RM, Temkin N, Carney N, Dikmen S, Rondina C, Videtta W, Petroni G, Lujan S, Pridgeon J, Barber J, Machamer J, Chaddock K, Celix JM, Cherner M, Hendrix T, Global Neurotrauma Research G (2012) A trial of intracranial-pressure monitoring in traumatic brain injury. N Engl J Med 367:2471–2481CrossRefGoogle Scholar
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