Revisiting oxygen dissociation curves and bedside measured arterial saturation in critically ill children
The oxygen dissociation curve (ODC) relates the partial pressure of oxygen in the blood (pO2) to the hemoglobin oxygen saturation (SO2) [1, 2]. It is crucial in determining oxygen delivery to the tissues and fundamental to critical care practice . We aimed to revisit this curve in critically ill children using a large physiologic and laboratory dataset.
This study utilizes continuously recorded physiologic data (5,783,484 SpO2 values) and blood gas tests from patients ≤ 18 years of age (3582 patients with 112,101 tests) who were admitted to the critical care unit at the Hospital for Sick Children, Toronto. Details on data capture, analyses and discussion of the results can be found in the online supplementary material.
Oxygen dissociation curve
Peripheral oxygen saturation derived from the pulse oximeter
Blood hemoglobin oxygen saturation
Partial pressure of oxygen in the blood
Partial pressure of carbon dioxide in the blood
Compliance with ethical standards
Conflicts of interest
Peter Laussen—lead developer T3 software platform, and unpaid medical consultant Etiometry LLC, Boston, Massachusetts. None of the other authors have any conflict of interest.