Intensive Care Medicine

, Volume 45, Issue 11, pp 1612–1614 | Cite as

Electrically generated nitric oxide from air: a safe and economical treatment for pulmonary hypertension

  • Binglan Yu
  • Warren M. Zapol
  • Lorenzo BerraEmail author
What's New in Intensive Care

Electrically generated nitric oxide

Inhaled nitric oxide (NO) is a selective pulmonary vasodilator approved by the US Food and Drug Administration in 1999 for the treatment of persistent pulmonary hypertension of the newborn [ 1]. The current NO delivery system is large, heavy, cumbersome and expensive, requires a cylinder distribution network and a device to regulate NO levels, monitor nitrogen dioxide (NO 2), percent of O 2, and trained respiratory therapy staff. Several methods have been used to produce NO for biomedical applications, including chemical and electrical systems. However, these methods produce large amounts of NO 2 and ozone (O 3) toxic byproducts, requiring complex purification systems. Recently, we designed, developed, and tested a lightweight, portable, economical device generating NO by pulsed electrical discharge in air using a high-voltage resonant power supply, to produce low levels of NO 2 and O 3 [ 2]. The electrodes are powered by a microcontroller circuit. Energy...



This study was partially supported by Grants from NHLBI Grant #R21HL130956 to B.Y., NHLBI B-BIC/NCAI #U54HL119145 to W.M.Z., and NIH/NHLBI Grant #1K23HL128882-01A1 to L.B. This study was also supported by laboratory funds of the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital (MGH).

Compliance with ethical standards

Conflicts of interest

B.Y. and W.M.Z. have patents at MGH on the electric generation of nitric oxide (NO). W.M.Z. is on the scientific advisory board of Third Pole Inc., which has licensed patents on NO generators from MGH. Other authors declare no conflicts of interest.

Supplementary material

134_2019_5756_MOESM1_ESM.docx (19 kb)
Supplementary material 1 (DOCX 18 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Harvard Medical SchoolMassachusetts General HospitalBostonUSA

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