High-fidelity computational simulation to refine strategies for lung-protective ventilation in paediatric acute respiratory distress syndrome

  • Sina Saffaran
  • Anup Das
  • Jonathan G. Hardman
  • Nadir YehyaEmail author
  • Declan G. BatesEmail author



DGB and JGH acknowledge funding from the UK Engineering and Physical Sciences Research Council (Grant No. EP/P023444/1). NY acknowledges funding from the NIH (Grant No. NIH K23 HL-136688).

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflicts of interests.

Ethical approval

The study was reviewed by the CHOP Institutional Review Board, and requirement for informed consent was waived.

Supplementary material

134_2019_5559_MOESM1_ESM.docx (3.5 mb)
Supplementary material 1 (DOCX 3617 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of EngineeringUniversity of WarwickCoventryUK
  2. 2.Anaesthesia and Critical Care, Division of Clinical Neuroscience, School of MedicineUniversity of NottinghamNottinghamUK
  3. 3.Department of Anaesthesiology and Critical Care MedicineChildren’s Hospital of Philadelphia, University of PennsylvaniaPhiladelphiaUSA

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