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Intensive Care Medicine

, Volume 45, Issue 2, pp 236–239 | Cite as

Hemoadsorption with CytoSorb®

  • Elettra C. Poli
  • Thomas Rimmelé
  • Antoine G. SchneiderEmail author
What's New in Intensive Care

Background

Several extracorporeal blood purification techniques have been proposed in critically ill patients with sepsis and sepsis-like syndromes. Despite theoretical benefits, recent Surviving Sepsis Campaign guidelines have not formulated a recommendation in favour of or against such techniques and urged for further research [1]. In this context, CytoSorb® (CytoSorbents Corporation, NJ, USA) was recently licensed for extracorporeal cytokine removal within the European Union (EU).

Cytosorb ® cartridges contain biocompatible polystyrene divinylbenzene copolymer beads capable of adsorbing molecules of medium molecular weight using a combination of size exclusion and hydrophobic interactions [ 2]. They can be used in stand-alone mode (hemoperfusion) or inserted within a continuous renal replacement therapy (CRRT) circuit (associated with a conventional hemofilter), a cardiopulmonary bypass (CPB) or an extracorporeal membrane oxygenation circuit. CytoSorb ® (Fig.  1) removes a wide range...

Notes

Compliance with ethical standards

Conflicts of interest

EP has not disclosed any potential conflict of interest. TR has received speaker and consulting honoraria from Fresenius Medical Care, Baxter Healthcare Corp, Biomérieux, Medtronic and B. Braun. AS has received a grant from the Leenaards Foundation, speaker honoraria from Fresenius Medical Care, Baxter Healthcare Corp and consulting honoraria from B. Braun Melsungen AG. He is the principal investigator of the CCCC trial, a pilot trial evaluating the impact of Cytosorb during cardiac surgery (ClinicalTrials.gov (NCT02775123).

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature and ESICM 2018

Authors and Affiliations

  • Elettra C. Poli
    • 1
  • Thomas Rimmelé
    • 2
    • 3
  • Antoine G. Schneider
    • 1
    Email author
  1. 1.Service de Médecine Intensive AdulteCentre Hospitalier Universitaire VaudoisLausanneSwitzerland
  2. 2.Service d’anesthésie-réanimationHôpital Edouard HerriotLyonFrance
  3. 3.EA 7426 PI3 (Pathophysiology of Injury-Induced Immunosuppression)Université Claude Bernard Lyon I-Biomérieux-Hospices Civils de LyonLyonFrance

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