Intensive Care Medicine

, Volume 44, Issue 8, pp 1360–1361 | Cite as

Hypothesis: early renal replacement therapy increases mortality in critically ill patients with acute on chronic renal failure. A post hoc analysis of the AKIKI trial

  • S. Gaudry
  • C. Verney
  • D. Hajage
  • J. D. Ricard
  • Didier DreyfussEmail author


Compliance with ethical standards

Conflicts of interest

The authors declare that they have no competing interest.

Ethical standard statement

The original trial was approved by the ethical committee of the French Society of Intensive Care Medicine and by the competent French legal authority (Comité de Protection des Personnes d’Ile de France VI, ID RCB 2013-A00765-40, NCT01932190) for all participating centers.

Supplementary material

134_2018_5210_MOESM1_ESM.doc (57 kb)
Supplementary material 1 (DOC 57 kb)


  1. 1.
    Schetz M, Gunst J, De Vlieger G, Van den Berghe G (2015) Recovery from AKI in the critically ill: potential confounders in the evaluation. Intensive Care Med 41:1648–1657CrossRefPubMedGoogle Scholar
  2. 2.
    Hsu C, Chertow GM, McCulloch CE et al (2009) Nonrecovery of kidney function and death after acute on chronic renal failure. Clin J Am Soc Nephrol 4:891–898CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Gaudry S, Hajage D, Schortgen F et al (2016) Initiation strategies for renal-replacement therapy in the intensive care unit. N Engl J Med 375(2):122–133CrossRefPubMedGoogle Scholar
  4. 4.
    Gaudry S, Hajage D, Schortgen F et al (2015) Comparison of two strategies for initiating renal replacement therapy in the intensive care unit: study protocol for a randomized controlled trial (AKIKI). Trials 16:170CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Smith OM, Wald R, Adhikari NKJ et al (2013) Standard versus accelerated initiation of renal replacement therapy in acute kidney injury (STARRT-AKI): study protocol for a randomized controlled trial. Trials 14:320CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature and ESICM 2018

Authors and Affiliations

  • S. Gaudry
    • 1
    • 2
  • C. Verney
    • 1
  • D. Hajage
    • 3
    • 4
    • 5
  • J. D. Ricard
    • 1
    • 6
  • Didier Dreyfuss
    • 1
    • 6
    • 7
    Email author
  1. 1.AP-HP, Service de Réanimation Médico-Chirurgicale, Hôpital Louis MourierColombesFrance
  2. 2.French National Institute of Health and Medical Research (INSERM), UMR_S1155, Remodeling and Repair of Renal Tissue, HôpitalTenonParisFrance
  3. 3.INSERM, ECEVE, U1123, CIC 1421ParisFrance
  4. 4.Univ Paris Diderot, Sorbonne Paris Cité, ECEVE, UMRS 1123ParisFrance
  5. 5.Département de Biostatistiques, Santé Publique et Information MédicaleAP-HP, Hôpital Pitié-SalpêtrièreParisFrance
  6. 6.Univ Paris Diderot, IAME, UMR 1137, Sorbonne Paris CitéParisFrance
  7. 7.Intensive Care UnitHôpital Louis MourierColombesFrance

Personalised recommendations