Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Elevated soluble IL-7 receptor concentration in non-survivor ICU patients

This is a preview of subscription content, log in to check access.

Fig. 1


  1. 1.

    Landelle C, Lepape A, Voirin N et al (2010) Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock. Intensive Care Med 36:1859–1866

  2. 2.

    Demaret J, Villars-Méchin A, Lepape A et al (2014) Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients. Intensive Care Med 40:1089–1096

  3. 3.

    Friggeri A, Cazalis M-A, Pachot A et al (2016) Decreased CX3CR1 messenger RNA expression is an independent molecular biomarker of early and late mortality in critically ill patients. Crit Care 20:204

  4. 4.

    Mazzucchelli R, Durum SK (2007) Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol 7:144–154

Download references


The authors gratefully acknowledge the MIP-Réa study group for their participation in the MIP-Réa clinical study. The authors also would like to thank Hélène Vallin, Nathalie Panel, Marion Provent, and Sylvie De La Salle for their great help in patients’ inclusion and Anne Portier for the clinical samples management. The authors thank Caroline Le Gall from Methodomics for statistical analysis. Funding was provided by the authors’ institutions (Hospices Civils de Lyon and bioMérieux) and was part of ADNA (Advanced Diagnostic for New Therapeutic Approaches), a program dedicated to personalized medicine, coordinated by Institut Mérieux and supported by the French public agency BPI France.

Author information

Correspondence to Estelle Peronnet.

Ethics declarations

Conflicts of interest

All authors work in a joint research unit, co-funded by the Hospices Civils de Lyon and bioMérieux. FV, GM, and AL are co-inventors in two patents families covering soluble CD127 biomarkers. This does not alter the authors’ adherence to all the Intensive Care Medicine policies on sharing data and materials.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (PDF 230 kb)

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Peronnet, E., Mouillaux, J., Monneret, G. et al. Elevated soluble IL-7 receptor concentration in non-survivor ICU patients. Intensive Care Med 42, 1639–1640 (2016). https://doi.org/10.1007/s00134-016-4445-x

Download citation


  • Intensive Care Unit Patient
  • Septic Shock Patient
  • sCD127 Level
  • Ethical Institutional Review Board
  • Receptor Alpha Chain