Our paper 20 years later: the unfulfilled promises of nebulised adrenaline in acute severe asthma
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Asthma is a prevalent non-communicable disease affecting around 300 million persons worldwide with an age-standardized death rate that decreased by no less than 41 % between 1990 and 2013 . However, the majority of remaining asthma deaths (67 %) are deemed preventable especially in young asthmatics . Childhood asthma has indeed become more frequent and severe. Preventable asthma mortality is related to poor adherence to treatment, inadequate assessment of asthma severity and that of ongoing attacks leading to implementing non-appropriate treatment .
Inhaled selective β2 agonists, systemic corticosteroids and supplemental oxygen represent the mainstay for the treatment of acute asthma, with addition of ipratropium bromide and magnesium sulfate in severe cases . Short-acting selective β2 agonists and systemic corticosteroids act through the relief of the main components of bronchial obstruction in acute asthma: the muscle-related bronchial narrowing and the...
KeywordsAsthma Salbutamol Salmeterol Terbutaline Formoterol
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