What’s new in bacterial meningitis
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Primary prevention of bacterial meningitis—predominantly through vaccination programs—is of paramount importance, since mortality and long-term disabling sequelae remain substantial . Routine vaccination also offers herd immunity for the unvaccinated population . The most illustrative example of such a major impact is the introduction of meningococcal conjugate vaccines . Vaccination against serogroup A in Africa and serogroup C in Europe have decreased its incidence by 95 % or more . A novel, four-component, recombinant, meningococcal serogroup B vaccine was shown to be immunogenic and safe in two randomized controlled trials testing infants and children . Implementation of this vaccine may further decrease invasive meningococcal disease, but decreasing rates of penicillin susceptibility and the possible resurgence of the disease remain a public health threat . Of concern is a recent international outbreak of MenC:cc11 disease among gay men, and the demonstrated...
KeywordsStatus Epilepticus Bacterial Meningitis Conjugate Vaccine Decompressive Craniectomy Moderate Hypothermia
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All authors declared that they have no conflicts of interest.
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