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What’s new in the controversy on the renal/tissue toxicity of starch solutions?

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References

  1. 1.

    Wiedermann CJ, Joannidis M (2013) Accumulation of hydroxyethyl starch in human and animal tissues: a systematic review. Intensive Care Med. doi:10.1007/s00134-013-3156-9

  2. 2.

    Wittbrodt P, Haase N, Butowska D, Winding R, Poulsen JB, Perner A (2013) Quality of life and pruritus in patients with severe sepsis resuscitated with hydroxyethyl starch long-term follow-up of a randomised trial. Crit Care 17:R58

  3. 3.

    Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K (2008) Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 358:125–139

  4. 4.

    Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Aneman A, Madsen KR, Moller MH, Elkjaer JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, Soe-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quist L, Nielsen J, Andersen LH, Holst LB, Thormar K, Kjaeldgaard AL, Fabritius ML, Mondrup F, Pott FC, Moller TP, Winkel P, Wetterslev J (2012) Hydroxyethyl starch 130/0.4 versus Ringer’s acetate in severe sepsis. N Engl J Med 367:124–134

  5. 5.

    Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McGuinness S, Rajbhandari D, Taylor CB, Webb SA (2012) Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med 367:1901–1911

  6. 6.

    Muller RG, Haase N, Wetterslev J, Perner A (2013) Effects of hydroxyethyl starch in subgroups of patients with severe sepsis: exploratory post hoc analyses of a randomised trial. Intensive Care Med 39:1963–1971

  7. 7.

    Gattas DJ, Dan A, Myburgh J, Billot L, Lo S, Finfer S (2013) Fluid resuscitation with 6 % hydroxyethyl starch (130/0.4 and 130/0.42) in acutely ill patients: systematic review of effects on mortality and treatment with renal replacement therapy. Intensive Care Med 39:558–568

  8. 8.

    Haase N, Perner A, Hennings LI, Siegemund M, Lauridsen B, Wetterslev M, Wetterslev J (2013) Hydroxyethyl starch 130/0.38–0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis. BMJ 346:f839

  9. 9.

    Patel A, Waheed U, Brett SJ (2013) Randomised trials of 6 % tetrastarch (hydroxyethyl starch 130/0.4 or 0.42) for severe sepsis reporting mortality: systematic review and meta-analysis. Intensive Care Med 39:811–822

  10. 10.

    Perel P, Roberts I, Ker K (2013) Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev 2:CD000567

  11. 11.

    Serpa Neto A, Veelo DP, Peireira VG, de Assuncao MS, Manetta JA, Esposito DC, Schultz MJ (2013) Fluid resuscitation with hydroxyethyl starches in patients with sepsis is associated with an increased incidence of acute kidney injury and use of renal replacement therapy: a systematic review and meta-analysis of the literature. J Crit Care. doi:10.1016/j.jcrc.2013.09.031

  12. 12.

    Zarychanski R, Abou-Setta AM, Turgeon AF, Houston BL, McIntyre L, Marshall JC, Fergusson DA (2013) Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. JAMA 309:678–688

  13. 13.

    Mutter TC, Ruth CA, Dart AB (2013) Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function. Cochrane Database Syst Rev 7:CD007594

  14. 14.

    Gillies MA, Habicher M, Jhanji S, Sander M, Mythen M, Hamilton M, Pearse RM (2013) Incidence of postoperative death and acute kidney injury associated with i.v. 6 % hydroxyethyl starch use: systematic review and meta-analysis. Br J Anaesth 112:25–34

  15. 15.

    Martin C, Jacob M, Vicaut E, Guidet B, Van Aken H, Kurz A (2013) Effect of waxy maize-derived hydroxyethyl starch 130/0.4 on renal function in surgical patients. Anesthesiology 118:387–394

  16. 16.

    James MF, Michell WL, Joubert IA, Nicol AJ, Navsaria PH, Gillespie RS (2011) Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (fluids in resuscitation of severe trauma). Br J Anaesth 107:693–702

  17. 17.

    Annane D, Siami S, Jaber S, Martin C, Elatrous S, Declere AD, Preiser JC, Outin H, Troche G, Charpentier C, Trouillet JL, Kimmoun A, Forceville X, Darmon M, Lesur O, Regnier J, Abroug F, Berger P, Clec’h C, Cousson J, Thibault L, Chevret S (2013) Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial. JAMA 310:1809–1817

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Conflicts of interest

NL and EH declare no conflicts of interest.

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Correspondence to Eric Hoste.

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Lameire, N., Hoste, E. What’s new in the controversy on the renal/tissue toxicity of starch solutions?. Intensive Care Med 40, 427–430 (2014). https://doi.org/10.1007/s00134-013-3191-6

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Keywords

  • Renal Replacement Therapy
  • Acute Kidney Injury
  • European Medicine Agency
  • Hydroxyethyl Starch
  • Starch Solution