Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Association between early detection of soluble TNF-receptors and mortality in burn patients

  • 53 Accesses

  • 8 Citations


Objectives: To describe early sequential profiling of circulating levels of tumor necrosis factor alpha (TNF-α), TNF-1 and TNF-2 soluble receptors (sTNFR1 and sTNFR2), and of endothelin (ET-1) in patients with severe burn injury, and its association with mortality. Design: Prospective study. Setting: Intensive Care Burn Unit at a community hospital. Patients: Twenty patients with total burn surface area (TBSA)≥30%. Interventions: None. Measurements and results: Patients were enrolled within 6 h from the injury. Blood samples were drawn at zero, 6, 12, and 24 h for sequential ELISA measurement of plasma marker levels. Data are expressed as mean±SD. Age, TBSA, and inhalation injury were not significantly different between survivors (n=9; 30±13 years, TBSA 40±12%) and nonsurvivors (n=11, 38±15 years, TBSA 56±20%). sTNFR1 levels were increased in nonsurvivors (2937±1676 pg/ml; 4548±1436 pg/ml) as compared to survivors (1313±561 pg/ml; 2561±804 pg/ml) at 6 h and 24 h, respectively (P=0.01 and 0.002). sTNFR2 levels were significantly increased in nonsurvivors (4617±1,876 pg/ml vs 2611±1,326 pg/ml) only at 6 h (P=0.015). TNF-α and ET-1 levels were not different between nonsurvivors and survivors. After adjustment for TBSA, sTNFR1 and sTNFR2 remained significantly higher in nonsurvivors. Conclusion: Early and progressive increase in sTNFR1 and sTNFR2 levels is associated with higher risk for poor outcome in severely burned patients.

This is a preview of subscription content, log in to check access.

Author information

Additional information

Electronic Publication

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ribeiro, C., Andrade, C., Polanczyk, C. et al. Association between early detection of soluble TNF-receptors and mortality in burn patients. Intensive Care Med 28, 472–478 (2002). https://doi.org/10.1007/s00134-001-1190-5

Download citation

  • Burns Inflammation TNF-receptors Mortality Prognosis