Der Orthopäde

, Volume 47, Issue 12, pp 1032–1035 | Cite as

Zoledronic acid

Treatment option for Gorham-Stout disease
  • Ozge Gulsum IlleezEmail author
  • Korhan Ozkan
  • Feyza Unlu Ozkan
  • Ali Burak Bostan
  • Fuat Akpinar
  • Bilge Bilgic
  • Ilknur Aktas


Gorham-Stout disease is a rare bone resorption disease, the etiology and prognosis of which is uncertain but it is thought to be benign. It can involve one or more bones and can cause pain, swelling, deformity and fractures in affected bones. Diagnosis is made with a combination of clinical, radiological and histopathological examinations once other causes of osteolysis have been excluded. Due to its rarity, there is no standard therapeutic approach.


Bone Fractures Osteolysis Pain Case report 



Alkaline phosphatase




Computed tomography


Gorham-Stout disease


Multiple myeloma


Positron emission tomography-CT


Parathyroid hormone


Vascular endothelial growth factor


Zoledronic acid


Behandlungsoption für das Gorham-Stout-Syndrom


Das Gorham-Stout-Syndrom ist eine seltene Erkrankung, bei der es zu einem Knochenabbau kommt. Ätiologie und Prognose sind ungewiss, aber es gilt als benigne. Es kann ein oder mehrere Knochen betreffen, dabei kann es zu Schmerzen, Schwellungen, Deformitäten und Frakturen in den betroffenen Knochen kommen. Die Diagnose wird anhand einer Kombination aus klinischen, radiologischen und histopathologischen Untersuchungen gestellt, sofern andere Ursachen für die Osteolyse ausgeschlossen wurden. Aufgrund seiner Seltenheit gibt es keine Standardtherapie für diese Erkrankung.


Knochen Frakturen Osteolyse Schmerzen Fallbericht 


Compliance with ethical guidelines

Conflict of interest

O.G. Illeez, K. Ozkan, F.U. Ozkan, A.B. Bostan, F. Akpinar, B. Bilgic and I. Aktas declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors. For images or other information within the manuscript which identify patients, consent was obtained from them and/or their legal guardians.


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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  • Ozge Gulsum Illeez
    • 1
    Email author
  • Korhan Ozkan
    • 2
  • Feyza Unlu Ozkan
    • 1
  • Ali Burak Bostan
    • 2
  • Fuat Akpinar
    • 2
  • Bilge Bilgic
    • 3
  • Ilknur Aktas
    • 1
  1. 1.Fatih Sultan Mehmet Training and Research Hospital, Department of Physical Medicine and RehabilitationUniversity of Health SciencesIstanbulTurkey
  2. 2.Faculty of Medicine, Göztepe Training and Research Hospital, Department of Orthopaedics and TraumatologyIstanbul Medeniyet UniversityIstanbulTurkey
  3. 3.Istanbul Faculty of Medicine, Department of PathologyIstanbul UniversityIstanbulTurkey

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