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Molekulare Mechanismen der Embryoimplantation im Endometrium

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Zusammenfassung

Die menschliche Reproduktion und die Implantation des Embryos sind ein komplexer und dadurch störungsanfälliger Prozess. Ein genauer Zeitplan bestimmt die Synchronisation der Blastozystenreifung und die endometriale Vorbereitung auf die Einnistung. Eine Vertiefung unseres Wissens über die molekularen Abläufe während der physiologischen Präimplantationsentwicklung und Implantation sollte zu einer Verbesserung der In-vitro-Kulturbedingungen und damit ultimativ zu einer Steigerung der Erfolgsraten der In-vitro-Fertilisationsbehandlung führen. In dem vorliegenden Beitrag werden molekulare Mechanismen, wie hormonelle Faktoren, Zytokin- und Wachstumsfaktorensysteme, die Bedeutung von Metalloproteinasen und Adhäsionsmolekülen kurz beschrieben und in den Kontext aktueller Forschung gestellt. Die weitere Erforschung dieser Zusammenhänge wird verantwortlich dafür sein, dass in Zukunft ein besseres klinisches sowie therapeutisches Management im Hinblick auf Sterilität, Infertilität, jedoch auch Kontrazeption entwickelt werden kann.

Abstract

Human Reproduction is a very complex and surprisingly inefficient process. The embryo development and the generation of a receptive endometrium needs an exact timing and synchronization. Understanding the factors involved in preimplantation embryo development and embryo-maternal interaction and implantation is crucial for improving success rates in reproductive medicine. The purpose of the present review is to describe briefly the function of adhesion- and hormonal factors, cytokines, growth factors and metalloproteinases. A better understanding of the molecular mechanisms of implantation will be responsible for the improvement of clinical and therapeutical management of sterility, infertility and contraception.

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Correspondence to Dr. A. Schanz.

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Schanz, A., Hess, A., Shahin, A. et al. Molekulare Mechanismen der Embryoimplantation im Endometrium. Gynäkologe 37, 123–127 (2004). https://doi.org/10.1007/s00129-003-1477-4

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Schlüsselwörter

  • Reproduktion
  • Implantation
  • Infertilität
  • Blastozyste
  • Kontrazeption

Keywords

  • Reproduction
  • Implantation
  • Infertility
  • Blastocyste
  • Contraception