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Chronic Toxicological Effects of Carbamazepine on Daphnia magna Straus: Effects on Reproduction Traits, Body Length, and Intrinsic Growth

  • Yu Tian
  • Xiaoming Xia
  • Jinhua WangEmail author
  • Lusheng Zhu
  • Jun Wang
  • Fengzhao Zhang
  • Zulfiqar Ahmad
Article

Abstract

In recent years, pharmaceuticals and personal care products (PPCPs) that remain in the environment have become increasingly important. Carbamazepine (CBZ) is a widely used antiepileptic drug that has a potential impact on the environment due to its Physico-chemical properties, which are rarely eliminated in conventional water treatment. Daphnia magna Straus (DMS) is a fundamental link of aquatic ecosystem chain. The influence of CBZ toxicity on DMS can effectively reflect the effects of CBZ toxicity on the aquatic environment. In this study, DMS was used as a subject to assess the chronic effects of CBZ exposure. It was found that after 21 days of CBZ exposure, the breeding frequency, the total number of eggs laid, body length, and intrinsic growth rate of DMS decreased with increasing CBZ concentrations. Maximum reductions of 69% in fecundity and 60% in fertility were observed at 0.5 mg/L CBZ, while a maximum reduction of 60% in body length was observed at 0.001 mg/L CBZ concentration. The integrated biomarker response version 2 (IBRv2) analysis suggests that with the increase in CBZ concentration, the overall negative effect of CBZ on DMS was enhanced.

Keywords

Carbamazepine Daphnia magna Straus Chronic toxicity Reproduction rate Inhibition 

Notes

Acknowledgements

The present study was supported by Grants from the National Natural Science Foundation of China [No. 41671320]; the National Science and Technology Major Project of the Ministry of Science and Technology of China [No. 2016YFD0201203]; the Natural Science Foundation of Shandong Province, China [Nos. JQ201711 and ZR2016JL029].

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yu Tian
    • 1
  • Xiaoming Xia
    • 2
  • Jinhua Wang
    • 1
    Email author
  • Lusheng Zhu
    • 1
  • Jun Wang
    • 1
  • Fengzhao Zhang
    • 1
  • Zulfiqar Ahmad
    • 3
    • 4
  1. 1.College of Resources and EnvironmentShandong Agricultural UniversityTaianChina
  2. 2.College of Plant ProtectionShandong Agricultural UniversityTaianChina
  3. 3.State Key Laboratory of Water Resources and Hydropower Engineering ScienceWuhan UniversityWuhanChina
  4. 4.Department of Environmental SciencesUniversity of CaliforniaRiversideUSA

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