Human Biological Monitoring of Mercury Through Hair Samples in China

  • Ping Li
  • Shuhui Guo
  • Jiating Zhao
  • Yuxi Gao
  • Yu-Feng LiEmail author
Focused Review


Mercury (Hg) is a global pollutant that affects environmental and human health. Considering the high toxicity of Hg, it is required to assess the exposure of Hg in human body for appropriate risk management. In this review paper, we summarized data obtained through regional and small-scaled human biomonitoring (HBM) program for Hg in hair samples in China, which can deliver scientific data to make decisions on environmental health policy. Besides, the major conclusions got from this study and perspectives for future works through these HBM program in China were presented. To better understand the current situation of hair Hg levels in China, a well-coordinated and designed national HBM program is urgently needed considering the requirements of the Minamata Convention on Mercury for effectiveness evaluation.


Mercury Hair samples China Human biomonitoring 



The authors are grateful for the financial support from the National Natural Science Foundation of China (11475196, 41573132, and 41622208), Ministry of Science and Technology of China (2016YFA0201600) and Guizhou Department of Science and Technology (No. QKH-2016-2804).


  1. Ba Y, Zhang Y, Cui L, Cheng X, Yang J, Liu H, Yang J, Qin J (1996) Using urinary and hair mercury levels as human biomorning index in mercury contaminated areas (in Chinese). J Chin Health Lab Technol 6:268–270Google Scholar
  2. Cai S, Lv H, Su H, Guo J (2014) Research on the relationship between hair mercury and teh frequency of fish-eating in pregant women in Wujiang (in Chinese with English abstract). Chin Foreign Med Res 12:91–92Google Scholar
  3. Cao M (2002) The normal hair mercury level in 143 Taiyuan residents (in Chinese). J Pract Med Technol 9:841–841Google Scholar
  4. CDC (2015) Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables. National Center for Environmental Health, Division of Laboratory Sciences, Centers for Disease Control Prevention, AtlantaGoogle Scholar
  5. Černá M, Puklová V, Hanzlíková L, Sochorová L, Kubínová R (2017) 25 years of HBM in the Czech Republic. Int J Hyg Environ Health 220:3–5. CrossRefGoogle Scholar
  6. Chai Z, Stemshorn B, Hao J, Jiang G, Hu J, Feng X, Lan H, Sun Y, Larssen T, Lahl U, den Herder K, Chin C, Baird S (2011) Special policy study on mercury management in China. The China Council for International Cooperation on Environment and Development, BeijingGoogle Scholar
  7. Chen B, Wang Y (1978) The investigation on normal hair mercury levels (in Chinese). Henan Sci Technol:24–28Google Scholar
  8. Chen Y, Wang Z, Shi M (1993) Analysis of hair mercury levels in 211 samples in Fujian (in Chinese). Fujian Environ 10:15–16Google Scholar
  9. Chen Z, Zhang Q, Gan Z, Li L (2004) Analysis of the content of Hg in hair of preganant and parturient women and neonates in Luzhou City (in Chinese with English abstract). J Luzhou Med College 27:119–120Google Scholar
  10. Chien L, Gao CS, Lin HH (2010) Hair mercury concentration and fish consumption: risk and perceptions of risk among women of childbearing age. Environ Res 110:123–129CrossRefGoogle Scholar
  11. Choi J, Knudsen LE, Mizrak S, Joas A (2017a) Identification of exposure to environmental chemicals in children and older adults using human biomonitoring data sorted by age: Results from a literature review. Int J Hyg Environ Health 220:282–298. CrossRefGoogle Scholar
  12. Choi W, Kim S, Baek Y-W, Choi K, Lee K, Kim S, Yu SD, Choi K (2017b) Exposure to environmental chemicals among Korean adults-updates from the second Korean National Environmental Health Survey (2012–2014). Int J Hyg Environ Health 220:29–35. CrossRefGoogle Scholar
  13. Clarkson TW, Magos L, Myers GJ (2003) The toxicology of mercury—current exposures and clinical manifestations. N Engl J Med 349:1731–1737. CrossRefGoogle Scholar
  14. Department of Environmental Hygiene (1980) The normal hair mercury level in 667 Taiyuan residents (in Chinese). J Shanxi Med Univ 8:46–46Google Scholar
  15. Department of Hygiene of Jilin Medical University, Changchun Envionmetal Protection Monitoring Station, Fuyu Sanitation and antiepidemic Station (1977) The normal value of mercury in 839 residents hair samples from Changchun (in Chinese). J Hyg Res:265–267Google Scholar
  16. Dickman MD, Leung CK, Leong MK (1998) Hong Kong male subfertility links to mercury in human hair and fish. Sci Total Environ 214:165–174. CrossRefGoogle Scholar
  17. Dickman MD, Leung KMC, Koo LCL (1999) Mercury in human hair and fish: is there a Hong Kong male subfertility connection? Mar Pollut Bull 39:352–356. CrossRefGoogle Scholar
  18. Dong Y, Bai J, Cui Q, Li B, Li L (2002) The mercury level in children from industrial area of Shenyang city (in Chinese). Chin J Child Health Care 10:279–280Google Scholar
  19. Feng X (2005) Mercury pollution in China—an overview. In: Pirrone N, Mahaffey KR (eds) Dynamics of mercury pollution on regional and global scales: atmospheric processes and human exposures around the World. Springer, Boston, pp 657–678. CrossRefGoogle Scholar
  20. Feng X, Han Y (1988) Investigation of hair mercury levels in fishermen from Nansihu Lake (in Chinese). J Environ Health 5:35–36Google Scholar
  21. Feng W, Qian Q, Chai Z (1994) Study on the correlation between mercury contents in hair of lying-in women and their new-born babies by INAA (in Chinese). Nucl Technol 17:182–185Google Scholar
  22. Feng Q, Suzuki Y, Hisashige A (1998) Hair mercury levels of residents in China, Indonesia, and Japan. Arch Environ Health 53:36–43CrossRefGoogle Scholar
  23. Gao Y, Yan C-H, Tian Y, Wang Y, Xie H-F, Zhou X, Yu X-D, Yu X-G, Tong S, Zhou Q-X, Shen X-M (2007) Prenatal exposure to mercury and neurobehavioral development of neonates in Zhoushan City, China. Environ Res 105:390–399. CrossRefGoogle Scholar
  24. Guo B-Q, Cai S-Z, Guo J-L, Xu J, Wu W, Li H, Zhou X, Kim D-S, Yan C-H, Lü H-D (2013) Levels of prenatal mercury exposure and their relationships to neonatal anthropometry in Wujiang City, China. Environ Pollut 182:184–189. CrossRefGoogle Scholar
  25. Health Canada (2015) Results of the Canadian health measures survey cycle (2012–2013)Google Scholar
  26. Hui M, Wu Q, Wang S, Liang S, Zhang L, Wang F, Lenzen M, Wang Y, Xu L, Lin Z, Yang H, Lin Y, Larssen T, Xu M, Hao J (2017) Mercury flows in China and global drivers. Environ Sci Technol 51:222–231. CrossRefGoogle Scholar
  27. Jiang G-B, Shi J-B, Feng X-B (2006) Mercury pollution in China: an overview of the past and current sources of the toxic metal. Environ Sci Technol 40:3673–3678. Google Scholar
  28. Joas A, Schwedler G, Choi J, Kolossa-Gehring M (2017) Human biomonitoring: science and policy for a healthy future, April 17–19, 2016, Berlin, Germany. Int J Hyg Environ Health 220:299–304. CrossRefGoogle Scholar
  29. Kang H, Yang Z, He Y (1994) The normal hair mercury level in Kun district, Baotou city (in Chinese). J Baotou Med 18:44–45Google Scholar
  30. Li G, Zhou F (1993) Study on the normal hair mercury levels in Huangshi city (in Chinese). Chin Envion Sci Technol:40–41Google Scholar
  31. Li Z, Wang Q, Luo Y (2006) Exposure of the urban population to mercury in Changchun city, Northeast China. Environ Geochem Health 28:61–66. CrossRefGoogle Scholar
  32. Li Y-F, Chen C, Li B, Wang J, Gao Y, Zhao Y, Chai Z (2008) Scalp hair as a biomarker in environmental and occupational mercury exposed populations: suitable or not? Environ Res 107:39–44CrossRefGoogle Scholar
  33. Li P, Feng X, Qiu G, Wan Q (2011) Hair can be a good biomarker of occupational exposure to mercury vapor: simulated experiments and field data analysis. Sci Total Environ 409:4484–4488. CrossRefGoogle Scholar
  34. Li Y-F, Shang L, Zhao J, Hu H, Wang W (2018) Environmental bioinorganic chemistry of mercury. Science Press, BeijingGoogle Scholar
  35. Liu H, Li P (1991) The normal hair mercury level in Hohhot (in Chinese). Chin J Ind Hyg Occup Dis 9:40–41Google Scholar
  36. Liu JL, Xu XR, Yu S, Cheng H, Peng JX, Hong YG, Feng XB (2014) Mercury contamination in fish and human hair from Hainan Island, South China Sea: implication for human exposure. Environ Res 135:42–47CrossRefGoogle Scholar
  37. Liu M, Chen L, He Y, Baumann Z, Mason RP, Shen H, Yu C, Zhang W, Zhang Q, Wang X (2018) Impacts of farmed fish consumption and food trade on methylmercury exposure in China. Environ Int 120:333–344. CrossRefGoogle Scholar
  38. Lye E, Legrand M, Clarke J, Probert A (2013) Blood total mercury concentrations in the Canadian population: Canadian Health Measures Survey Cycle 1, 2007–2009. Can J Public Health 104:e246–e251. CrossRefGoogle Scholar
  39. Niu X, Zhang Y, Zhou J (2012) Comparison of mercury levels of general residents in coastal and inland areas (in Chinese). Environ Chem 31:1942–1947Google Scholar
  40. Niu X, Sun Q, Guo M, Zhou J, Zhang Y (2014) Mercury exposure for general residents in Dalian urban area (in Chinese with English abstract). Asian J Ecotoxicol 9:940–949Google Scholar
  41. Niu Z, Wang Y, Liu G (2016) Investigation on hair mercury concentration of people in 8 typical regions of Anhui Province and its influence factors (in Chinese with English abstract). Environ Chem 35:533–539Google Scholar
  42. Park C, Hwang M, Kim H, Ryu S, Lee K, Choi K, Paek D (2016) Early snapshot on exposure to environmental chemicals among Korean adults—results of the first Korean National Environmental Health Survey (2009–2011). Int J Hyg Environ Health 219:398–404. CrossRefGoogle Scholar
  43. Prüss-Ustün A, Wolf J, Corvalán C, Neville T, Bos R, Neira M (2017) Diseases due to unhealthy environments: an updated estimate of the global burden of disease attributable to environmental determinants of health. J Public Health (Oxf) 39:464–475. Google Scholar
  44. Shao Y (1977) The normal hair mercury levels in 500 samples from urban and suburb area of Hangzhou. J Hyg Res:395–401Google Scholar
  45. Song L (2010) Human hair mercury levels in the residents living in Shanghai and the environmental influecing factors (in Chinese with English abstract). East China Normal UniversityGoogle Scholar
  46. Song Y, Yang J, Li J, Cheng J, Wang W (2007) Investigation of the mercury contents in the hair of 262 Ningbo residents (in Chinese with English abstract). Occup Health 23:282–283Google Scholar
  47. Song G, Lv H, Guo J, Chen M, Su H (2013) Analysis and evaluation to mercury content in cord blood and fetal hair of 2316 neonates (in Chinese). Lab Med Clin 10:1208–1209Google Scholar
  48. Tian W (2011) Human exposure level and risk assessment of total mercury and methylmercury in the Pearl River Delta (in Chinese). Jinan UniversityGoogle Scholar
  49. UNEP (2013) Minamata convention on mercury. United Nations Environment Programme, GeneveGoogle Scholar
  50. Wang J, Zhang Y (1981) Study on the normal hair mercury level in Chengdu (in Chinese). Chin J Environ Eng:52–55Google Scholar
  51. Wang H, Wu J, Zhou Q, Ying T, Shen Z (2010) Survey on maternal mercury exposure and its association with neonate in Zhoushan islands (in Chinese with English abstract). Chin Prev Med 11:1081–1084Google Scholar
  52. Wu S, Gu T, Hu X, Gao Y, Gao S (1982) Analysis of mercury in 324 hair samples from Shijiazhuang residents (in Chinese). J Hebei Med Univ 3:205–206Google Scholar
  53. Wu Y, Zhao Y, Li J (2018) The fifth China total diet study. Science Press, BeijingGoogle Scholar
  54. Xu L, Mo Y (1981) Normal mercury level in 543 hair samples from Qinghai (in Chinese). Qinghai Med J:26–28Google Scholar
  55. Xu X, Wang W-X (2017) Mercury exposure and source tracking in distinct marine-caged fish farm in southern China. Environ Pollut 220:1138–1146. CrossRefGoogle Scholar
  56. Yan J, Gao ZY, Wang J, Yan CH (2017) Hair mercury levels and their relationship with seafood consumption among preschool children in Shanghai. Biomed Environ Sci 30:220–223. Google Scholar
  57. Yang S (2011) Clinic investigation on mercury in maternity and newborn and their corelation (in Chinese). J Fujian Med Univ 45:427–429Google Scholar
  58. Yang H, Chen X (1987) Analysis of mercury in 209 hair samples from Guiyang, Guizhou, China (in Chinese). Ind Health Occup Dis 13:226–227Google Scholar
  59. Yin C, Guo H, Jin Y, Li W, Liu J, Zhang H (1980) Hair mercury (total mercury and methylmercury) levels in Beijing Residents (in Chinese). J Hyg Res:56–59Google Scholar
  60. Yin C, Guo H, Li W, Zhang S (1981) Mercury investigation in hair samples from fishermen and farms in five provinces around Bohai Sea and Yellow Sea (in Chinese). J Hyg Res:12–14Google Scholar
  61. Yin L, Yu K, Lin S, Song X, Yu X (2016) Associations of blood mercury, inorganic mercury, methyl mercury and bisphenol A with dental surface restorations in the U.S. population, NHANES 2003–2004 and 2010–2012. Ecotoxicol Environ Saf 134:213–225. CrossRefGoogle Scholar
  62. Zhang Y (2003) Investigation of the accumulation of Pb, Cd and Hg and their health effects in Suizhou residents (in Chinese). Suzhou UniversityGoogle Scholar
  63. Zhang L (2009) Study on the human hair mercury levels in the residents living in the different function regions in Qingdao and influence factors (in Chinese with English abstract). J Saf Environ 9:95–97Google Scholar
  64. Zhang P, Chen G, Zhang B (1988) Investigation on the mercury contamination in Qingtongxia reservior and its impact on fish, poultry and human hair mercury levels (in Chinese). J Environ Health:31–32Google Scholar
  65. Zhang W, Ren A, Yang Z, Pei L, Hao L, Xie Q, Jiang Y, Wei Y, Li Z (2005) Correlation studies of trace elements in mother’s hair, venous blood and cord blood (in Chinese with English abstact). Chin J Reprod Health 16:209–212Google Scholar
  66. Zhang X, Cui X, Lin C, Ma J, Liu X, Zhu Y (2017) Reference levels and relationships of nine elements in first-spot morning urine and 24-h urine from 210 Chinese children. Int J Hyg Environ Health 220:227–234. CrossRefGoogle Scholar
  67. Zidek A, Macey K, MacKinnon L, Patel M, Poddalgoda D, Zhang Y (2017) A review of human biomonitoring data used in regulatory risk assessment under Canada’s Chemicals Management Program. Int J Hyg Environ Health 220:167–178. CrossRefGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Environmental Geochemistry, Institute of GeochemistryChinese Academy of SciencesGuiyangChina
  2. 2.Division of Mercury Convention Implementation, Foreign Economic Cooperation OfficeMinistry of Ecology and EnvironmentBeijingChina
  3. 3.CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, and HKU-IHEP Joint Laboratory on Metallomics, Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina

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