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Coartemether Induced Oxidative and Hepatic Damage in Plasmodium berghei Strain Anka Infected Mice

  • God’swill Nduka AnyasorEmail author
  • Isaac Olayinka Oyewole
  • Kayode Olushola Ogunwenmo
  • Adegoke Ayowole
Article
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Abstract

This study investigated the effect of coartemether on antioxidant and hepatotoxic biomarkers in Plasmodium berghei infected mice. Erythrocyte, hepatic and renal superoxide dismutase (2.71 ± 0.51; 1.96 ± 0.87; 2.84 ± 0.22 Units/mg protein respectively) and catalase (4.10 ± 0.10; 8.25 ± 1.24; 6.28 ± 0.11 Units/mg protein respectively) activities were significantly (p < 0.05) elevated in “parasitized and treated” (PnT) animals. Renal glutathione level (19.02 ± 0.20 μg/mL) was elevated in PnT animals. Glutathione S-transferase and malondialdehyde levels in hepatic (8.76 ± 0.49 μmol/min/mg; 527.23 ± 24.56 mmol/dL) and renal (3.35 ± 0.30 μmol/min/mg; 464.42 ± 59.13 mmol/dL) tissues were significantly high (p < 0.05) in coartemether-treated animals alone. Plasma aspartate transferase (9.45 ± 3.59 U/L) and alanine transferase (5.78 ± 2.36 U/L) were high in PnT animals. Therefore, data indicates that in the presence of P. berghei, coartemether could alter the antioxidant status and induce hepatotoxic damage in mice.

Keywords

Antioxidant Tissues Mice Plasmodium berghei 

Notes

Acknowledgments

We express gratitude to Babcock University Administration for their support. We are grateful to the Head of Department of Chemical and Environmental Sciences, Babcock University Prof. E. B. Esan for constant encouragement, support and critique of the manuscript. Our appreciation goes to Anyasor Chiamaka O. for typesetting and editing of the manuscript. We declare no conflict of interest and are solely responsible for the writing and content of this work.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • God’swill Nduka Anyasor
    • 1
    Email author
  • Isaac Olayinka Oyewole
    • 2
  • Kayode Olushola Ogunwenmo
    • 1
  • Adegoke Ayowole
    • 1
  1. 1.Department of Chemical and Environmental SciencesSchool of Science and Technology, Babcock UniversityIkejaNigeria
  2. 2.Department of Biosciences and BiotechnologySchool of Science and Technology, Babcock UniversityIkejaNigeria

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