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Diabetologia

pp 1–10 | Cite as

Trends in cancer mortality among people with vs without diabetes in the USA, 1988–2015

  • Jessica L. HardingEmail author
  • Linda J. Andes
  • Edward W. Gregg
  • Yiling J. Cheng
  • Hannah K. Weir
  • Kai M. Bullard
  • Nilka Ríos Burrows
  • Giuseppina Imperatore
Article

Abstract

Aims/hypothesis

Cancer-related death is higher among people with vs without diabetes. However, it is not known if this excess risk has changed over time or what types of cancer may be driving these changes.

Methods

To estimate rates of site-specific cancer mortality in adults with vs without self-reported diagnosed diabetes, we used data from adults aged ≥18 years at the time of the interview who participated in the 1985—2012 National Health Interview Survey. Participants’ data were linked to the National Death Index by the National Center for Health Statistics to determine vital status and cause of death through to the end of 2015. Cancer deaths were classified according to underlying cause of death. Death rates for five time periods (1988–1994, 1995–1999, 2000–2004, 2005–2009, 2010–2015) were estimated using discrete Poisson regression models adjusted for age, sex and race/ethnicity with p for linear trend reported (ptrend). Site-specific cancer mortality rates were stratified by diabetes status and period, and total cancer mortality rates were additionally stratified by sex, race/ethnicity, education and BMI status.

Results

Among adults with diabetes, age-adjusted cancer mortality rates (per 10,000 person-years) declined 25.5% from 39.1 (95% CI 30.1, 50.8) in 1988–1994 to 29.7 (26.6, 33.1) in 2010–2015, ptrend < 0.001. Among adults without diabetes, rates declined 25.2% from 30.9 (28.6, 33.4) in 1988–1994 to 23.2 (22.1, 24.2) in 2010–2015, ptrend < 0.01. Adults with diabetes remained approximately 30% more likely to die from cancer than people without diabetes, and this excess risk did not improve over time. In adults with diabetes, cancer mortality rates did not decline in some population subgroups (including black people, people with lower levels of education and obese people), and the excess risk increased for obese adults with vs without diabetes. Declines in total cancer mortality rates in adults with diabetes appear to be driven by large relative declines in cancers of the pancreas (55%) and breast (65%), while for lung cancer, declines are modest (7%).

Conclusions/interpretation

Declines in cancer mortality rates were observed in adults with and without diabetes. However, adults with diabetes continue to be more likely to die from cancer than people without diabetes. This study highlights the continued need for greater cancer risk-factor mitigation, especially in adults with diabetes.

Keywords

Cancer Diabetes Epidemiology Mortality Trends 

Abbreviations

NCHS

National Center for Health Statistics

NDI

National Death Index

NHIS

National Health Interview Survey

Notes

Acknowledgements

The authors thank the women and men who participated in the study, as well as all of the staff involved at the NCHS for the study design, data collection and data dissemination.

Contribution statement

JLH conducted the literature search, contributed to the conception and design of the study, interpreted the data and wrote the article. LJA contributed to the design of the study, performed the statistical analysis, assisted in drafting the article and revised the article for important intellectual content. YJC provided technical statistical support and revised the article for important intellectual content. KMB, EWG, HKW and NRB contributed to the design of the study and revised the manuscript for important intellectual content. GI conceived and designed the study and revised the manuscript for important intellectual content. JLH is the guarantor of this work and, as such, had full access to the all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. All authors approved the final version of the manuscript.

Funding

This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

Duality of interest

The authors declare that there is no duality of interest associated with this manuscript.

Supplementary material

125_2019_4991_MOESM1_ESM.pdf (230 kb)
ESM Tables (PDF 230 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Jessica L. Harding
    • 1
    Email author
  • Linda J. Andes
    • 1
  • Edward W. Gregg
    • 1
  • Yiling J. Cheng
    • 1
  • Hannah K. Weir
    • 2
  • Kai M. Bullard
    • 1
  • Nilka Ríos Burrows
    • 1
  • Giuseppina Imperatore
    • 1
  1. 1.Division of Diabetes TranslationCenters for Disease Control and PreventionAtlantaUSA
  2. 2.Division of Cancer Prevention and ControlCenters for Disease Control and PreventionAtlantaUSA

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